BMS-599626 dihydrochloride is a small molecule pan-HER inhibitor that targets the human epidermal growth factor receptor family, specifically inhibiting HER1 (IC50=20 nmol/L) and HER2 (IC50=30 nmol/L) kinase activities. This compound functions by competing with ATP for binding to these receptors, thereby blocking their kinase activity and downstream signaling pathways through the inhibition of heterodimer formation between HER1 and HER2. BMS-599626 dihydrochloride serves as a valuable tool for investigating the antitumor effects in various tumor models overexpressing HER1 and HER2.
BMS-599626 dihydrochloride is a small molecule pan-HER inhibitor that targets the human epidermal growth factor receptor family, specifically inhibiting HER1 (IC50=20 nmol/L) and HER2 (IC50=30 nmol/L) kinase activities. This compound functions by competing with ATP for binding to these receptors, thereby blocking their kinase activity and downstream signaling pathways through the inhibition of heterodimer formation between HER1 and HER2. BMS-599626 dihydrochloride serves as a valuable tool for investigating the antitumor effects in various tumor models overexpressing HER1 and HER2.
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