BMS-986318 is a potent non-bile acid agonist of the farnesoid X receptor (FXR), exhibiting EC50 values of 53 nM and 350 nM in FXR Gal4 and SRC-1 recruitment assays, respectively. This compound possesses a favorable ADME profile and has demonstrated efficacy in preclinical models of liver cholestasis and fibrosis, particularly in mouse bile duct ligation studies. BMS-986318 is suitable for research related to nonalcoholic steatohepatitis and its potential therapeutic implications.
BMS-986318 is a potent non-bile acid agonist of the farnesoid X receptor (FXR), exhibiting EC50 values of 53 nM and 350 nM in FXR Gal4 and SRC-1 recruitment assays, respectively. This compound possesses a favorable ADME profile and has demonstrated efficacy in preclinical models of liver cholestasis and fibrosis, particularly in mouse bile duct ligation studies. BMS-986318 is suitable for research related to nonalcoholic steatohepatitis and its potential therapeutic implications.
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