Bobcat339 hydrochloride is a potent and selective cytosine-based inhibitor of TET (ten-eleven translocation) enzymes, with IC₅₀ values of 33 μM for TET1 and 73 μM for TET2. By inhibiting TET-mediated DNA demethylation, it modulates epigenetic regulation and gene transcription. Bobcat339 hydrochloride is a valuable tool in epigenetics research and serves as a potential lead compound for developing therapeutics targeting DNA methylation-related diseases.
Bobcat339 hydrochloride is a potent and selective cytosine-based inhibitor of TET (ten-eleven translocation) enzymes, with IC₅₀ values of 33 μM for TET1 and 73 μM for TET2. By inhibiting TET-mediated DNA demethylation, it modulates epigenetic regulation and gene transcription. Bobcat339 hydrochloride is a valuable tool in epigenetics research and serves as a potential lead compound for developing therapeutics targeting DNA methylation-related diseases.
Product Information
Catalog Num
A24343
Formula
C16H13Cl2N3O
Molecular Weight
334.20
CAS Number
2436747-44-1
SMILES
NC1=NC(N(C2=CC=CC(C3=CC=CC=C3)=C2)C=C1Cl)=O.Cl
Storage
Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
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