Fig. 1 · Structure
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Boc-12-Ado-OH
PROTAC Linker
Boc-12-Ado-OH serves as a versatile PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an alkane chain with a terminal carboxylic acid and Boc-protected amino groups, enabling it to react with primary amines in the presence of coupling reagents such as EDC or HATU to form stable amide linkages. The Boc group can be selectively deprotected under mild acidic conditions, yielding a free amine suitable for further chemical modifications and biological applications in targeted protein degradation studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 18934-81-1 |
| Applications | PROTAC Linker |
| Formula | C17H33NO4 |
| Molecular Weight | 315.45 |
| SMILES | CC(OC(NCCCCCCCCCCCC(O)=O)=O)(C)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.