BRAF V600E/CRAF-IN-2

Catalog No.: A40723
BRAF V600E/CRAF Inhibitor
BRAF V600E/CRAF-IN-2 is a potent inhibitor targeting BRAF V600E and CRAF, demonstrating IC50 values of 0.888 μM and 0.229 μM, respectively. This compound induces apoptosis and effectively causes cell cycle arrest at the G0/G1 phase in HCT-116 colon cancer cells. BRAF V600E/CRAF-IN-2 is suitable for research applications focused on cancer biology and treatment strategies.
Grouped product items
Size Price Stock Qty
25mg
$1,275.00
In stock
50mg
$1,625.00
In stock
100mg
$2,000.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionBRAF V600E/CRAF-IN-2 is a potent inhibitor targeting BRAF V600E and CRAF, demonstrating IC50 values of 0.888 μM and 0.229 μM, respectively. This compound induces apoptosis and effectively causes cell cycle arrest at the G0/G1 phase in HCT-116 colon cancer cells. BRAF V600E/CRAF-IN-2 is suitable for research applications focused on cancer biology and treatment strategies.
Product Information
Catalog NumA40723
FormulaC30H30F3N5O2
Molecular Weight549.59
CAS Number2499499-62-4
SMILESCCN1CCN(CC1)C2=CC(C(F)(F)F)=CC(C(NC3=CC=CC(NC4=NC5=CC=CC(OC)=C5C=C4)=C3)=O)=C2
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