Braftide is an allosteric inhibitor of BRAF kinase that targets the dimer interface, effectively preventing the formation of BRAF dimers. It exhibits inhibitory activity against both wild-type BRAF and the oncogenic variant BRAFG469A, with IC50 values of 364 nM and 172 nM, respectively. By inhibiting the MAPK signaling pathway, Braftide demonstrates the ability to suppress the proliferation of KRAS mutant tumor cells, with EC50 values of 7.1 µM and 6.6 µM for HCT116 and HCT-15 cell lines, respectively. This compound is applicable in various cancer research studies.
Braftide is an allosteric inhibitor of BRAF kinase that targets the dimer interface, effectively preventing the formation of BRAF dimers. It exhibits inhibitory activity against both wild-type BRAF and the oncogenic variant BRAFG469A, with IC50 values of 364 nM and 172 nM, respectively. By inhibiting the MAPK signaling pathway, Braftide demonstrates the ability to suppress the proliferation of KRAS mutant tumor cells, with EC50 values of 7.1 µM and 6.6 µM for HCT116 and HCT-15 cell lines, respectively. This compound is applicable in various cancer research studies.
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