Breast cancer targeting peptide 18–4 is a KRT1 receptor-targeting peptide characterized by a binding affinity (Kd) of 0.98 μM. This peptide, with the amino acid sequence WxEAAYQrFL, serves as an analogue of the P160 peptide. When covalently conjugated with the anticancer peptide MccJ25, it significantly enhances the cellular uptake of MccJ25 in breast cancer cells, thereby improving its anticancer efficacy. The resulting conjugate demonstrates IC50 values of 14.2, 20, and 25 μM against MCF-7, MDA-MB-435, and MDA-MB-435-MDR cell lines, respectively, making it valuable for research in breast cancer therapy.
Breast cancer targeting peptide 18–4 is a KRT1 receptor-targeting peptide characterized by a binding affinity (Kd) of 0.98 μM. This peptide, with the amino acid sequence WxEAAYQrFL, serves as an analogue of the P160 peptide. When covalently conjugated with the anticancer peptide MccJ25, it significantly enhances the cellular uptake of MccJ25 in breast cancer cells, thereby improving its anticancer efficacy. The resulting conjugate demonstrates IC50 values of 14.2, 20, and 25 μM against MCF-7, MDA-MB-435, and MDA-MB-435-MDR cell lines, respectively, making it valuable for research in breast cancer therapy.
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