Brexpiprazole-d8-1 is a stable isotope-labeled form of Brexpiprazole, an atypical antipsychotic agent. It functions as a partial agonist at the human 5-HT1A and dopamine D2L receptors, exhibiting affinities (Ki values) of 0.12 nM and 0.3 nM, respectively. Additionally, it acts as an antagonist at the 5-HT2A receptor with a Ki of 0.47 nM, and demonstrates potent antagonistic activity at noradrenergic α1B and α2C receptors with Ki values of 0.17 nM and 0.59 nM, respectively. This compound is suited for studies involving neuropharmacology and receptor interaction analysis.
Brexpiprazole-d8-1 is a stable isotope-labeled form of Brexpiprazole, an atypical antipsychotic agent. It functions as a partial agonist at the human 5-HT1A and dopamine D2L receptors, exhibiting affinities (Ki values) of 0.12 nM and 0.3 nM, respectively. Additionally, it acts as an antagonist at the 5-HT2A receptor with a Ki of 0.47 nM, and demonstrates potent antagonistic activity at noradrenergic α1B and α2C receptors with Ki values of 0.17 nM and 0.59 nM, respectively. This compound is suited for studies involving neuropharmacology and receptor interaction analysis.
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