Brexpiprazole-d8 is a deuterium-labeled derivative of Brexpiprazole, an atypical antipsychotic agent. Acting primarily as a partial agonist at the human 5-HT1A and dopamine D2L receptors, it exhibits Ki values of 0.12 nM and 0.3 nM, respectively. Additionally, Brexpiprazole functions as a 5-HT2A receptor antagonist with a Ki of 0.47 nM and exhibits significant antagonistic activity at noradrenergic α1B (Ki=0.17 nM) and α2C receptors (Ki=0.59 nM). This reagent is suitable for various research applications including pharmacological studies and mechanism of action investigations.
Brexpiprazole-d8 is a deuterium-labeled derivative of Brexpiprazole, an atypical antipsychotic agent. Acting primarily as a partial agonist at the human 5-HT1A and dopamine D2L receptors, it exhibits Ki values of 0.12 nM and 0.3 nM, respectively. Additionally, Brexpiprazole functions as a 5-HT2A receptor antagonist with a Ki of 0.47 nM and exhibits significant antagonistic activity at noradrenergic α1B (Ki=0.17 nM) and α2C receptors (Ki=0.59 nM). This reagent is suitable for various research applications including pharmacological studies and mechanism of action investigations.
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