BRL-41992 is a selective antagonist of the α₂B-adrenergic receptor, demonstrating 94-fold greater selectivity for this subtype compared to the α₂A-receptor. It exhibits Kᵢ values of 1.1 nM in neonatal rat lung tissue, where the α₂B-receptor is expressed, and 103.3 nM in human platelet membranes, which express the α₂A-receptor. This compound is valuable for studying the functional differences between α₂ receptor subtypes in various biological contexts.
BRL-41992 is a selective antagonist of the α₂B-adrenergic receptor, demonstrating 94-fold greater selectivity for this subtype compared to the α₂A-receptor. It exhibits Kᵢ values of 1.1 nM in neonatal rat lung tissue, where the α₂B-receptor is expressed, and 103.3 nM in human platelet membranes, which express the α₂A-receptor. This compound is valuable for studying the functional differences between α₂ receptor subtypes in various biological contexts.
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