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CAL-101 (GS-1101, Idelalisib)


PI3K inhibitor

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Catalog No. A10172

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
CAL-101 10mg A10172-10

Regular Price: €38.00

Special Price: €34.20

CAL-101 25mg A10172-25

Regular Price: €85.50

Special Price: €76.95

CAL-101 50mg A10172-50

Regular Price: €152.00

Special Price: €136.80

CAL-101 100mg A10172-100

Regular Price: €285.00

Special Price: €256.50

CAL-101 (GS-1101) 10mM * 1mL in DMSO A10172-10mM-D

Regular Price: €72.20

Special Price: €64.98

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

CAL-101 is an isoform-selective inhibitor of PI3K that induces apoptosis of chronic lymphocytic leukemia (CLL) cells.

CAL-101 (GS-1101, Idelalisib)

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Publications citing Adooq Products
CAL-101 (GS-1101, Idelalisib) Citations (3)
  • Hirosumi Tamura, .et al. Evaluation of anticancer agents using patient-derived tumor organoids characteristically similar to source tissues, Oncol Rep, 2018, Aug; 40(2): 635-646 PMID: 29917168
  • Pridham KJ, .et al. PIK3CB/p110β is a selective survival factor for glioblastoma, Neuro Oncol, 2018, Mar 27;20(4):494-505 PMID: 29016844
  • Yoshihiro Umezawa, .et al. Molecular mechanisms for enhancement of stromal cell-derived factor 1-induced chemotaxis by platelet endothelial cell adhesion molecule 1 (PECAM-1), J Biol Chem, 2017, Dec 1; 292(48): 19639-19655 PMID: 28974577

Chemical Information

Catalog Num A10172
Actions Inhibitor
M. Wt 415.4
Formula C22H18FN7O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 870281-82-6
Synonyms CAL101
SMILES CC[[email protected]@H](C1=NC2=C(C(=CC=C2)F)C(=O)N1C3=CC=CC=C3)NC4=NC=NC5=C4NC=N5

Biological Activity

CAL-101 is an isoform-selective inhibitor of PI3K that induces apoptosis of chronic lymphocytic leukemia (CLL) cells.
Target Value
p110δIC50: 2.5nM
p110γIC50: 89nM
p110βIC50: 565nM
p110αIC50: 820nM
hVps34IC50: 978nM
C2βIC50: >1μM
mTORIC50: >1μM
PIP5KαIC50: >1μM
PIP5KβIC50: >1μM
DNA-PKIC50: 6.729μM


Solubility (25°C) * In vitro DMSO 83 mg/mL (199.79 mM)
Water <1 mg/mL (<1 mM)
Ethanol 35 mg/mL (84.25 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.07 mL 120.37 mL 240.73mL
0.5 mM 4.81 mL 24.07 mL 48.15 mL
1 mM 2.41 mL 12.04 mL 24.07 mL
5 mM 0.48 mL 2.41 mL 4.81 mL

*The above data is based on the productmolecular weight 415.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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