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CAL-101 (GS-1101, Idelalisib)

Catalog No.: A10172

PI3K inhibitor

CAL-101 (GS-1101, Idelalisib)

CAL-101 (GS-1101, Idelalisib) Chemical Structure

CAS NO. 870281-82-6

CAL-101 is an isoform-selective inhibitor of PI3K that induces apoptosis of chronic lymphocytic leukemia (CLL) cells.

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10 mg
25 mg
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100 mg
10mM * 1mL in DMSO
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  • Ming-Chun Hung, .et al. AKT phosphorylation as a predictive biomarker for PI3K/mTOR dual inhibition-induced proteolytic cleavage of mTOR companion proteins in small cell lung cancer, Cell Biosci, 2022, 12: 122 PMID: 35918763
  • Hirosumi Tamura, .et al. Evaluation of anticancer agents using patient-derived tumor organoids characteristically similar to source tissues, Oncol Rep, 2018, Aug; 40(2): 635-646 PMID: 29917168
  • Pridham KJ, .et al. PIK3CB/p110β is a selective survival factor for glioblastoma, Neuro Oncol, 2018, Mar 27;20(4):494-505 PMID: 29016844
  • Yoshihiro Umezawa, .et al. Molecular mechanisms for enhancement of stromal cell-derived factor 1?Cinduced chemotaxis by platelet endothelial cell adhesion molecule 1 (PECAM-1), J Biol Chem, 2017, Dec 1; 292(48): 19639-19655 PMID: 28974577

Biological Activity

CAL-101 is an isoform-selective inhibitor of PI3K that induces apoptosis of chronic lymphocytic leukemia (CLL) cells.
Target Value
p110δIC50: 2.5nM
p110γIC50: 89nM
p110βIC50: 565nM
p110αIC50: 820nM
hVps34IC50: 978nM
C2βIC50: >1μM
mTORIC50: >1μM
PIP5KαIC50: >1μM
PIP5KβIC50: >1μM
DNA-PKIC50: 6.729μM
In vitro (25°C) DMSO Warmed: 76 mg/mL (182.94 mM)
Water Insoluble
Ethanol 21 mg/mL (50.55 mM)
In vivo 2% DMSO+20%PEG 300+ddH2O 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.07 mL 120.37 mL 240.73 mL
0.5 mM 4.81 mL 24.07 mL 48.15 mL
1 mM 2.41 mL 12.04 mL 24.07 mL
5 mM 0.48 mL 2.41 mL 4.81 mL

*The above data is based on the productmolecular weight 415.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10172
Actions Inhibitor
CAS No. 870281-82-6
Formula C22H18FN7O
M. Wt 415.4
Purity >98%
Synonyms CAL101
SMILES CC[[email protected]@H](C1=NC2=C(C(=CC=C2)F)C(=O)N1C3=CC=CC=C3)NC4=NC=NC5=C4NC=N5

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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