Calcicludine

Catalog No.: A66178
Calcium Channel Inhibitor
Calcicludine is a potent inhibitor of high-voltage-activated calcium channels, with a particular affinity for L-type calcium channels. Derived from the venom of the green mamba, this protein toxin plays a critical role in studies investigating calcium signaling and neurotransmitter release. Its unique mechanism makes Calcicludine a valuable tool for researchers exploring neuronal excitability and muscle contraction pathways.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionCalcicludine is a potent inhibitor of high-voltage-activated calcium channels, with a particular affinity for L-type calcium channels. Derived from the venom of the green mamba, this protein toxin plays a critical role in studies investigating calcium signaling and neurotransmitter release. Its unique mechanism makes Calcicludine a valuable tool for researchers exploring neuronal excitability and muscle contraction pathways.
Product Information
Catalog NumA66178
FormulaC321H476N86O78S6
Molecular Weight6980.13
CAS Number178036-64-1
SequenceTrp-Gln-Pro-Pro-Trp-Tyr-Cys-Lys-Glu-Pro-Val-Arg-Ile-Gly-Ser-Cys-Lys-Lys-Gln-Phe-Ser-Ser-Phe-Tyr-Phe-Lys-Trp-Thr-Ala-Lys-Lys-Cys-Leu-Pro-Phe-Leu-Phe-Ser-Gly-Cys-Gly-Gly-Asn-Ala-Asn-Arg-Phe-Gln-Thr-Ile-Gly-Glu-Cys-Arg-Lys-Lys-Cys-Leu-Gly-Lys (Disulfide bridge: Cys7-Cys57; Cys16-Cys40; Cys32-Cys53)
Sequence shorteningWQPPWYCKEPVRIGSCKKQFSSFYFKWTAKKCLPFLFSGCGGNANRFQTIGECRKKCLGK (Disulfide bridge: Cys7-Cys57; Cys16-Cys40; Cys32-Cys53)
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