Camidanlumab tesirine is an antibody-drug conjugate (ADC) that targets CD25, utilizing the HuMax-TAC human IgG1 monoclonal antibody. This compound is conjugated via a cleavable dipeptide linker to a pyrrolobenzodiazepine (PBD) dimer, achieving a drug-antibody ratio of 2.3. Camidanlumab tesirine demonstrates exceptional affinity for human CD25 at the picomolar level and exhibits potent cytotoxic effects against various CD25-expressing human lymphoma cell lines, positioning it as a promising candidate for targeted cancer therapies.
Camidanlumab tesirine is an antibody-drug conjugate (ADC) that targets CD25, utilizing the HuMax-TAC human IgG1 monoclonal antibody. This compound is conjugated via a cleavable dipeptide linker to a pyrrolobenzodiazepine (PBD) dimer, achieving a drug-antibody ratio of 2.3. Camidanlumab tesirine demonstrates exceptional affinity for human CD25 at the picomolar level and exhibits potent cytotoxic effects against various CD25-expressing human lymphoma cell lines, positioning it as a promising candidate for targeted cancer therapies.
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