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Catalog No.: A11100

SGLT2 Inhibitor


Canagliflozin Chemical Structure

CAS NO. 842133-18-0

Canagliflozin is an inhibitor of subtype 2 sodium-glucose transport protein (SGLT2).

Availability: In stock

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5 mg
10 mg
50 mg
100 mg
10mM * 1mL in DMSO
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • David Papadopoli, .et al. Perturbations of cancer cell metabolism by the antidiabetic drug canagliflozin, Neoplasia, 2021, Apr;23(4):391-399 PMID: 33784591
  • Angelopoulou A, .et al. Canagliflozin-loaded magnetic nanoparticles as potential treatment of hypoxic tumors in combination with radiotherapy, Nanomedicine, 2018, Oct;13(19):2435-2454 PMID: 30311542

Biological Activity

Canagliflozin is an inhibitor of subtype 2 sodium-glucose transport protein (SGLT2).
mSGLT2 (Cell-free assay) rSGLT2 (Cell-free assay) hSGLT2 (Cell-free assay)
2 nM3.7 nM4.4 nM
In vitro (25°C) DMSO 79 mg/mL (177.71 mM)
Water Insoluble
Ethanol Insoluble
In vivo 0.5% CMC+0.25% Tween 80 17 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.5 mL 112.49 mL 224.97 mL
0.5 mM 4.5 mL 22.5 mL 44.99 mL
1 mM 2.25 mL 11.25 mL 22.5 mL
5 mM 0.45 mL 2.25 mL 4.5 mL

*The above data is based on the productmolecular weight 444.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11100
Actions Inhibitor
CAS No. 842133-18-0
Formula C24H25FO5S
M. Wt 444.5
Purity >98%
SMILES CC1=C(C=C(C=C1)[[email protected]]2[[email protected]@H]([[email protected]]([[email protected]@H]([[email protected]](O2)CO)O)O)O)CC3=CC=C(S3)C4=CC=C(C=C4)F

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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