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- David Papadopoli, .et al. Perturbations of cancer cell metabolism by the antidiabetic drug canagliflozin, Neoplasia, 2021, Apr;23(4):391-399 PMID: 33784591
- Angelopoulou A, .et al. Canagliflozin-loaded magnetic nanoparticles as potential treatment of hypoxic tumors in combination with radiotherapy, Nanomedicine, 2018, Oct;13(19):2435-2454 PMID: 30311542
Biological Activity
Canagliflozin is an inhibitor of subtype 2 sodium-glucose transport protein (SGLT2).
Targets
| mSGLT2 (Cell-free assay) | rSGLT2 (Cell-free assay) | hSGLT2 (Cell-free assay) | ||
| 2 nM | 3.7 nM | 4.4 nM |
| In vitro (25°C) | DMSO | 79 mg/mL (177.71 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 0.5% CMC+0.25% Tween 80 | 17 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.5 mL | 112.49 mL | 224.97 mL |
| 0.5 mM | 4.5 mL | 22.5 mL | 44.99 mL |
| 1 mM | 2.25 mL | 11.25 mL | 22.5 mL |
| 5 mM | 0.45 mL | 2.25 mL | 4.5 mL |
*The above data is based on the productmolecular weight 444.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11100 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 842133-18-0 |
| Formula | C24H25FO5S |
| M. Wt | 444.5 |
| Purity | >98% |
| SMILES | CC1=C(C=C(C=C1)[[email protected]]2[[email protected]@H]([[email protected]]([[email protected]@H]([[email protected]](O2)CO)O)O)O)CC3=CC=C(S3)C4=CC=C(C=C4)F |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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