Candesartan (Atacand)

Catalog No.: A10175

RAAS antagonist

Candesartan (Atacand)

Candesartan (Atacand) Chemical Structure

CAS NO. 139481-59-7

Candesartan is an angiotensin receptor blocker (also called an angiotensin-II receptor antagonist or an AIIRA).

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5 mg

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10 mg

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50 mg

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100 mg

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10mM * 1mL in DMSO

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Special Price $48.00

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  • Hideki Kobara, .et al. Antihypertensive drug telmisartan inhibits cell proliferation of gastrointestinal stromal tumor cells in vitro, Molecular Medicine Reports, 2020, 22(2)
  • Dao-Lai Zhang, .et al. Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility, eLife, 2018, 7: e33432 PMID: 29393851
  • Toshihide Kashihara, .et al. Angiotensin II activates CaV1.2 Ca2+ channels through β‐arrestin2 and casein kinase 2 in mouse immature cardiomyocytes, J Physiol, 2017, Jul 1; 595(13): 4207-4225 PMID: 28295363
  • >

Biological Activity

Candesartan is an angiotensin receptor blocker (also called an angiotensin-II receptor antagonist or an AIIRA).
Targets
AT1 receptor
0.26 nM
In vitro (25°C) DMSO 79 mg/mL (179.36 mM)
Water Insoluble
Ethanol 1 mg/mL (2.27 mM)
In vivo 2% DMSO+40% PEG 300+2% Tween 80+ddH2O 9 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.7 mL 113.51 mL 227.01 mL
0.5 mM 4.54 mL 22.7 mL 45.4 mL
1 mM 2.27 mL 11.35 mL 22.7 mL
5 mM 0.45 mL 2.27 mL 4.54 mL

*The above data is based on the productmolecular weight 440.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10175
Actions Antagonist
CAS No. 139481-59-7
Formula C24H20N6O3
M. Wt 440.5
Purity >98%
Synonyms Blopress, Atacand, Amias, Ratacand
SMILES CCOC1=NC2=CC=CC(=C2N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5)C(=O)O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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