Casein kinase 1δ-IN-28

Catalog No.: A36947
CK1 Inhibitor
Casein kinase 1δ-IN-28 is a selective inhibitor of Casein Kinase 1 (CK1) with an IC50 of 0.0146 μM. This compound demonstrates significant potential for modulating CK1-mediated pathways, making it a valuable tool for studies in cell signaling and cancer research. Additionally, Casein kinase 1δ-IN-28 shows a metabolite rate of 52% in human liver microsomes, indicating its metabolic stability for in vitro applications.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionCasein kinase 1δ-IN-28 is a selective inhibitor of Casein Kinase 1 (CK1) with an IC50 of 0.0146 μM. This compound demonstrates significant potential for modulating CK1-mediated pathways, making it a valuable tool for studies in cell signaling and cancer research. Additionally, Casein kinase 1δ-IN-28 shows a metabolite rate of 52% in human liver microsomes, indicating its metabolic stability for in vitro applications.
Product Information
Catalog NumA36947
FormulaC23H23FN6
Molecular Weight402.47
CAS Number1095750-94-9
SMILESFC1=CC=C(C2=C(C3=CC=NC=C3)N4N=C(N5CCNC(C)(C5)C)C=CC4=N2)C=C1
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