CB1 antagonist 4 is a selective inverse agonist for the cannabinoid receptor 1 (CB1), demonstrating an IC50 of 8.5 nM in human CB1 assays. This compound exhibits a notable selectivity for CB1 over CB2 receptors, with an IC50 of 604.9 nM. CB1 antagonist 4 effectively inhibits GTP binding in CB1-overexpressing cell membranes, with an EC50 of 18.5 nM, making it a valuable tool for studying CB1 receptor biology and signaling pathways.
CB1 antagonist 4 is a selective inverse agonist for the cannabinoid receptor 1 (CB1), demonstrating an IC50 of 8.5 nM in human CB1 assays. This compound exhibits a notable selectivity for CB1 over CB2 receptors, with an IC50 of 604.9 nM. CB1 antagonist 4 effectively inhibits GTP binding in CB1-overexpressing cell membranes, with an EC50 of 18.5 nM, making it a valuable tool for studying CB1 receptor biology and signaling pathways.
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