CBB1007 trihydrochloride is a reversible and selective inhibitor of lysine-specific demethylase 1 (LSD1), exhibiting an IC50 of 5.27 µM for human LSD1. It effectively inhibits LSD1's demethylase activity on H3K4Me2 and H3K4Me, demonstrating notable selectivity for LSD1 over LSD2 and JARID1A. This compound has significant implications in cancer research, particularly in non-pluripotent models, as it promotes the expression of differentiation-related genes in pluripotent cells and is being explored in the context of teratocarcinoma, embryonic carcinoma, and seminoma.
CBB1007 trihydrochloride is a reversible and selective inhibitor of lysine-specific demethylase 1 (LSD1), exhibiting an IC50 of 5.27 µM for human LSD1. It effectively inhibits LSD1's demethylase activity on H3K4Me2 and H3K4Me, demonstrating notable selectivity for LSD1 over LSD2 and JARID1A. This compound has significant implications in cancer research, particularly in non-pluripotent models, as it promotes the expression of differentiation-related genes in pluripotent cells and is being explored in the context of teratocarcinoma, embryonic carcinoma, and seminoma.
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