CBIQ (4-Chlorobenzo[f]isoquinoline) functions as a chloride channel activator, specifically targeting the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- ion channels as well as the intermediate-conductance calcium-sensitive K+ channel (KCNN4). With Kd values of 0.1 μM for CFTR and 3.9 μM for KCNN4, CBIQ demonstrates significant potency. This compound is particularly valuable for research focused on cystic fibrosis and related ion transport disorders.
CBIQ (4-Chlorobenzo[f]isoquinoline) functions as a chloride channel activator, specifically targeting the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- ion channels as well as the intermediate-conductance calcium-sensitive K+ channel (KCNN4). With Kd values of 0.1 μM for CFTR and 3.9 μM for KCNN4, CBIQ demonstrates significant potency. This compound is particularly valuable for research focused on cystic fibrosis and related ion transport disorders.
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