Chloride Channels

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  1. Ivermectin is a broad-spectrum antiparasitic avermectin medicine.
  2. CFTR activator

    VX-770 (Ivacaftor) is known as a CFTR potentiator.
  3. CaCC blocker

    Talniflumate is a calcium-activated chloride channel (CaCC) (hCLCA1/mCLCA3) blocker; reduces mucin synthesis and release in cell culture and animal models.
  4. CaCCs Inhibitor

    CaCCinh-A01 inhibits CaCC currents in human bronchial and intestinal cells. Also inhibits TMEM16A channels (IC50 = 2.1 uM, in TMEM16A-expressing FRT cells).
  5. TMEM16A Inhibitor

    T16Ainh-A01 is a selective TMEM16A calcium-activated chloride channel inhibitor that strongly inhibits chloride current in salivary gland cells.
  6. CaCC activator

    Eact activates the Calcium-activated Chloride channel (CaCC) TMEM16A CaCC.
  7. chloride channel blocker

    NPPB is a chloride channel blocker (IC50 = 80 nM) that has also been identified as a GPR35 agonist.
  8. anion channel inhibitor

    Endovion (NS3728) is a pharmacological anion channel inhibitor (like chloride channel) and the specific VRAC/VSOAC blocker. Endovion (NS3728) is also an Anoctamin-1 (ANO 1) channel inhibitor.

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