CC-223

Catalog No.: A13078

mTOR Inhibitor

CC-223

CC-223 Chemical Structure

CAS NO. 1228013-30-6

CC-223 is a potent mTOR kinase inhibitor (IC50=16 nM), with >150-fold sensitivity over the related lipid kinase PI3K-alpha (IC50=4uM).

Availability: In stock

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5 mg

Regular Price: $120.00

Special Price $96.00

10 mg

Regular Price: $190.00

Special Price $152.00

25 mg

Regular Price: $390.00

Special Price $312.00

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Biological Activity

CC-223 is a potent mTOR kinase inhibitor (IC50=16 nM), with >150-fold sensitivity over the related lipid kinase PI3K-alpha (IC50=4uM).
Targets
mTOR cFMS FLT4 DNA-PK PI3K-α
16 nM28 nM651 nM840 nM4.0 μM
In vitro DMSO 70 mg/mL (176.11 mM)
Water Insoluble
Ethanol 70 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.16 mL 125.8 mL 251.59 mL
0.5 mM 5.03 mL 25.16 mL 50.32 mL
1 mM 2.52 mL 12.58 mL 25.16 mL
5 mM 0.5 mL 2.52 mL 5.03 mL

*The above data is based on the productmolecular weight 397.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13078
Actions Inhibitor
CAS No. 1228013-30-6
Formula C21H27N5O3
M. Wt 397.47
Purity >98%
Synonyms CC 223, CC223
SMILES CC(C)(C1=NC=C(C=C1)C2=CN=C3C(=N2)N(C(=O)CN3)C4CCC(CC4)OC)O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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