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$0.00 Biological Activity
CC-223 is a potent mTOR kinase inhibitor (IC50=16 nM), with >150-fold sensitivity over the related lipid kinase PI3K-alpha (IC50=4uM).
Targets
| mTOR | cFMS | FLT4 | DNA-PK | PI3K-α |
| 16 nM | 28 nM | 651 nM | 840 nM | 4.0 μM |
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 25.16 mL | 125.8 mL | 251.59 mL |
| 0.5 mM | 5.03 mL | 25.16 mL | 50.32 mL |
| 1 mM | 2.52 mL | 12.58 mL | 25.16 mL |
| 5 mM | 0.5 mL | 2.52 mL | 5.03 mL |
*The above data is based on the productmolecular weight 397.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A13078 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 397.47 |
| Formula | C21H27N5O3 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1228013-30-6 |
| Synonyms | CC 223, CC223 |
| SMILES | CC(C)(C1=NC=C(C=C1)C2=CN=C3C(=N2)N(C(=O)CN3)C4CCC(CC4)OC)O |
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