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CC-223

mTOR Inhibitor

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Catalog No. A13078

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
CC-223 5mg A13078-5
$120.00
CC-223 10mg A13078-10
$190.00
CC-223 25mg A13078-25
$390.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

CC-223 is a potent mTOR kinase inhibitor (IC50=16 nM), with >150-fold sensitivity over the related lipid kinase PI3K-alpha (IC50=4uM).

CC-223

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Chemical Information

Catalog Num A13078
Actions Inhibitor
M. Wt 397.47
Formula C21H27N5O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1228013-30-6
Synonyms CC 223, CC223
SMILES CC(C)(C1=NC=C(C=C1)C2=CN=C3C(=N2)N(C(=O)CN3)C4CCC(CC4)OC)O

Biological Activity

Description
CC-223 is a potent mTOR kinase inhibitor (IC50=16 nM), with >150-fold sensitivity over the related lipid kinase PI3K-alpha (IC50=4uM).
Targets
mTOR cFMS FLT4 DNA-PK PI3K-α
16 nM28 nM651 nM840 nM4.0 μM

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.16 mL 125.8 mL 251.59mL
0.5 mM 5.03 mL 25.16 mL 50.32 mL
1 mM 2.52 mL 12.58 mL 25.16 mL
5 mM 0.5 mL 2.52 mL 5.03 mL

*The above data is based on the productmolecular weight 397.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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