CC-930 (Tanzisertib)

Catalog No.: A13564

JNK inhibitor

CC-930 (Tanzisertib)

CC-930 (Tanzisertib) Chemical Structure

CAS NO. 899805-25-5

CC-930 is kinetically competitive with ATP in the JNK-dependent phosphorylation of the protein substrate c-Jun and potent against all isoforms of JNK (Ki(JNK1) = 44 ± 3 nM, IC50(JNK1) = 61 nM, Ki(JNK2) = 6.2 ± 0.6 nM, IC50(JNK2) = 5 nM, IC50(JNK3) = 5 nM) and selective against MAP kinases ERK1 and p38a with IC50 of 0.48 and 3.4 μM respectively

Availability: In stock

Package Price Qty
5 mg
$180.00
10 mg
$320.00
25 mg
$650.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

CC-930 is kinetically competitive with ATP in the JNK-dependent phosphorylation of the protein substrate c-Jun and potent against all isoforms of JNK (Ki(JNK1) = 44 ± 3 nM, IC50(JNK1) = 61 nM, Ki(JNK2) = 6.2 ± 0.6 nM, IC50(JNK2) = 5 nM, IC50(JNK3) = 5 nM) and selective against MAP kinases ERK1 and p38a with IC50 of 0.48 and 3.4 μM respectively
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.3 mL 111.5 mL 223 mL
0.5 mM 4.46 mL 22.3 mL 44.6 mL
1 mM 2.23 mL 11.15 mL 22.3 mL
5 mM 0.45 mL 2.23 mL 4.46 mL

*The above data is based on the productmolecular weight 448.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num A13564
Actions Inhibitor
M. Wt 448.44
Formula C21H23F3N6O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 899805-25-5
Synonyms Tanzisertib, CC 930, CC930
SMILES C1COC[[email protected]]1N2C3=NC(=NC=C3N=C2NC4=C(C=C(C=C4F)F)F)NC5CCC(CC5)O

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