CC-930 (Tanzisertib)

Catalog No.: A13564

JNK inhibitor

CC-930 (Tanzisertib)

CC-930 (Tanzisertib) Chemical Structure

CAS NO. 899805-25-5

CC-930 is kinetically competitive with ATP in the JNK-dependent phosphorylation of the protein substrate c-Jun and potent against all isoforms of JNK (Ki(JNK1) = 44 ± 3 nM, IC50(JNK1) = 61 nM, Ki(JNK2) = 6.2 ± 0.6 nM, IC50(JNK2) = 5 nM, IC50(JNK3) = 5 nM) and selective against MAP kinases ERK1 and p38a with IC50 of 0.48 and 3.4 μM respectively

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5 mg

Regular Price: $100.00

Special Price $80.00

10 mg

Regular Price: $165.00

Special Price $132.00

25 mg

Regular Price: $320.00

Special Price $256.00

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Biological Activity

CC-930 is kinetically competitive with ATP in the JNK-dependent phosphorylation of the protein substrate c-Jun and potent against all isoforms of JNK (Ki(JNK1) = 44 ± 3 nM, IC50(JNK1) = 61 nM, Ki(JNK2) = 6.2 ± 0.6 nM, IC50(JNK2) = 5 nM, IC50(JNK3) = 5 nM) and selective against MAP kinases ERK1 and p38a with IC50 of 0.48 and 3.4 μM respectively
In vitro DMSO Warmed: 80 mg/mL (164.98 mM)
Water Warmed: 4 mg/mL (8.24 mM)
Ethanol Warmed: 80 mg/mL (164.98 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.3 mL 111.5 mL 223 mL
0.5 mM 4.46 mL 22.3 mL 44.6 mL
1 mM 2.23 mL 11.15 mL 22.3 mL
5 mM 0.45 mL 2.23 mL 4.46 mL

*The above data is based on the productmolecular weight 448.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13564
Actions Inhibitor
CAS No. 899805-25-5
Formula C21H23F3N6O2
M. Wt 448.44
Purity >98%
Synonyms Tanzisertib, CC 930, CC930
SMILES C1COC[[email protected]]1N2C3=NC(=NC=C3N=C2NC4=C(C=C(C=C4F)F)F)NC5CCC(CC5)O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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