Biological Activity
CCT128930 is an ATP-competitive AKT inhibitor that is a potent, advanced lead pyrrolopyrimidine compound exhibiting selectivity for AKT over PKA, achieved by targeting a single amino acid difference.
Targets
Akt2 (Cell-free assay) | p70 S6K (Cell-free assay) | PKA (Cell-free assay) | ||
6 nM | 120 nM | 168 nM |
In vitro (25°C) | DMSO | 59 mg/mL (172.59 mM) | |
Water | Insoluble | ||
Ethanol | 5 mg/mL (14.63 mM) | ||
In vivo | 2% DMSO+30% PEG 300+2% Tween 80+ddH2O | 3 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 29.26 mL | 146.28 mL | 292.57 mL |
0.5 mM | 5.85 mL | 29.26 mL | 58.51 mL |
1 mM | 2.93 mL | 14.63 mL | 29.26 mL |
5 mM | 0.59 mL | 2.93 mL | 5.85 mL |
*The above data is based on the productmolecular weight 341.8 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A11031 |
---|---|
Actions | Inhibitor |
CAS No. | 885499-61-6 |
Formula | C18H20ClN5 |
M. Wt | 341.8 |
Purity | >98% |
Synonyms | CCT-128930 |
SMILES | C1CN(CCC1(CC2=CC=C(C=C2)Cl)N)C3=NC=NC4=C3C=CN4 |
Storage | Store lyophilized at -20ºC, keep desiccated. |
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