United States
You have no items in your shopping cart.
Publications citing Adooq Products
Chemical Information
| Catalog Num | A11031 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 341.8 |
| Formula | C18H20ClN5 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 885499-61-6 |
| Synonyms | CCT-128930 |
| SMILES | C1CN(CCC1(CC2=CC=C(C=C2)Cl)N)C3=NC=NC4=C3C=CN4 |
Description |
CCT128930 is an ATP-competitive AKT inhibitor that is a potent, advanced lead pyrrolopyrimidine compound exhibiting selectivity for AKT over PKA, achieved by targeting a single amino acid difference. | ||||||||||
Targets |
|
||||||||||
| Solubility (25°C) * | In vitro | DMSO | 68 mg/mL (198.92 mM) |
|---|---|---|---|
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | 6 mg/mL (17.55 mM) | ||
| In vivo | 1% DMSO/30% polyethylene glycol/1% Tween 80 | 11 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 29.26 mL | 146.28 mL | 292.57mL |
| 0.5 mM | 5.85 mL | 29.26 mL | 58.51 mL |
| 1 mM | 2.93 mL | 14.63 mL | 29.26 mL |
| 5 mM | 0.59 mL | 2.93 mL | 5.85 mL |
*The above data is based on the productmolecular weight 341.8 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Ordering online
To place an order online, simply browse to the product you are interested in and click on the 'Add to Cart' button. To complete this process, you will need to confirm the size and quantity of the products that you require.
To complete an order you will need to register using our simple online registration process. We do not share your contact details with any third parties.
When you are ready to check out simply enter your PO number to complete the ordering process. Please ensure that you send us a copy of your PO by fax or email afterwards. We will then liaise with you or your purchasing department to confirm the order.
Found your products but not ready to order?
Why not use our WishList feature to store lists of products? This convenient feature allows you to manage lists, append notes to products and share lists with co-workers or colleagues.
Ordering offline
You can email or fax us your purchase order and we will place the order for you. You can also phone us to place the order. Our contact details are:
- Tel: 866-930-6790
- Fax: 323-606-8156
- Email: [email protected]
We require the following information to process your order:
- The catalog number for each product.
- Your email address or fax number.
- Your name and telephone number.
- Shipping address and billing address.
- Purchase order numbers.
Similar product(s)
Special Price Starting at:
$54.00
MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM, respectively. ...
Special Price Starting at: $54.00
Special Price Starting at:
$60.00
TIC10 inactivates Akt and ERK to induce TRAIL through Foxo3a, possesses superior drug properties: delivery across the blood-brain barrier, superior stability and improved pharmacokinetics. ...
Special Price Starting at: $60.00
Special Price Starting at:
$126.00
A-674563 is a B/Akt inhibitor with an IC50 of 14 nM and also shows inhibitory activity against PKA and CDK2 with IC50 of 16 and 46 nM, respectively. ...
Special Price Starting at: $126.00
Special Price Starting at:
$100.00
Akt inhibitor GSK2141795 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apopto ...
Special Price Starting at: $100.00
Special Price Starting at:
$45.00
Deguelin is a natural product that displays profound antiproliferative activity. ...
Special Price Starting at: $45.00
Special Price Starting at:
$45.00
PHT-427 is a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor. ...
Special Price Starting at: $45.00
Special Price Starting at:
$160.00
AT7867 dihydrochloride is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively, little activity outside the AGC kinase family. ...
Special Price Starting at: $160.00
Special Price Starting at:
$72.00
GDC-0068 is a selective, ATP-competitive, pan-Akt inhibitor that targets Akt1, 2, and 3 with IC50 values of 5, 18, and 8 nM, respectively in cell-free assays ...
Special Price Starting at: $72.00
Special Price Starting at:
$67.50
GSK690693 is a novel ATP-competitive, low-nanomolar pan-Akt kinase inhibitor (IC50 values are 2, 13 and 9 nM of Akt1, 2 and 3 respectively). ...
Special Price Starting at: $67.50
Special Price Starting at:
$200.00
SR-13668 is an Akt inhibitor, is also an orally bioavailable indole-3-carbinol (I3C) analogue inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic and ...
Special Price Starting at: $200.00
Special Price Starting at:
$198.00
A-443654, a specific Akt inhibitor with Ki value of 160 pM, interferes with mitotic progression and bipolar spindle formation. ...
Special Price Starting at: $198.00
Special Price Starting at:
$320.00
Akt1 and Akt2-IN-1 is an allosteric inhibitor of Akt1 (IC50 = 3.5 nM) and Akt2 (IC50 = 42 nM), with potent and balanced activity. ...
Special Price Starting at: $320.00
Special Price Starting at:
$54.00
Perifosine (also KRX-0401) acts as an Akt inhibitor and a PI3K inhibitor. ...
Special Price Starting at: $54.00
Special Price Starting at:
$180.00
GNE-493 is potent, selective, and orally available pan-PI3-kinase and dual pan-PI3-kinase/mTOR inhibitor with potential anticancer activity. ...
Special Price Starting at: $180.00
Special Price Starting at:
$36.00
Honokiol is a lignan present in the cones, bark, and leaves of Magnolia grandiflora that has shown pro-apoptotic effects in melanoma, sarcoma, myeloma, leukemia, bladder, lung, prostate, oral squamous ...
Special Price Starting at: $36.00
Special Price Starting at:
$49.50
SC 66 is an allosteric inhibitor of Akt that facilitates both ubiquitination and deactivation of Akt. It exhibits anticancer activity in vitro and in vivo. ...
Special Price Starting at: $49.50
Special Price Starting at:
$76.50
Triciribine, also known as API-2, suppresses the phosphorylation level and kinase activity of Akt. ...
Special Price Starting at: $76.50
Special Price Starting at:
$72.00
Triciribine phosphate inhibits the phosphorylation, activation, and signalling of Akt-1, -2, and -3, which may result in the inhibition of Akt-expressing tumor cell proliferation. ...
Special Price Starting at: $72.00
Special Price Starting at:
$76.50
SC79 is an AKT activator. SC79 binds to the plecktrin homology (PH) domain of Akt that mimics the binding of PtdIns(3,4,5)P3 to induce a conformational change in Akt that enhances phosphorylation and ...
Special Price Starting at: $76.50
Special Price Starting at:
$350.00
KP372-1 is a synthetic small molecule AKT inhibitor. ...
Special Price Starting at: $350.00
Special Price Starting at:
$147.00
AT7867 is a novel and potent inhibitor of both AKT and the downstream kinase p70 S6 kinase (p70S6K) and also of protein kinase A. ...
Special Price Starting at: $147.00
Special Price Starting at:
$90.00
Afuresertib, also known as GSK2110183, is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. It binds to and inhib ...
Special Price Starting at: $90.00
Special Price Starting at:
$63.00
AZD5363 is a potent inhibitor of AKT with pharmacodynamic activity in vivo, has potential to treat a range of solid and hematologic tumors as monotherapy or a combinatorial agent. ...
Special Price Starting at: $63.00
Special Price Starting at:
$320.00
ARQ 092 is an oral activie, potent and selective AKT inhibitor with IC50 values: 5.0 nM (AKT1); 4.5 nM (AKT2); 16 nM (AKT3). ...
Special Price Starting at: $320.00
Special Price Starting at:
$90.00
Palomid 529 is a dual TORC1/2 inhibitor of the PI3K/Akt/mTOR pathway having broad activity in angiogenesis and cellular proliferation. ...
Special Price Starting at: $90.00
Special Price Starting at:
$100.00
10-DEBC HCl is a selective inhibitor of Akt/PKB. It inhibits IGF-1-stimulated phosphorylation and activation of Akt (complete inhibition at 2.5 μM), suppressing downstream activation of mTOR, p70 S6 ...
Special Price Starting at: $100.00
Special Price Starting at:
$81.00
AKT inhibitor VIII is a cell-permeable and reversible quinoxaline compound that potently and selectively inhibits Akt1/Akt2 activity (IC50 = 58 nM, 210 nM, and 2.12 ?M for Akt1, Akt2, and Akt3, respec ...
Special Price Starting at: $81.00
Special Price Starting at:
$80.00
TIC10 inactivates Akt and ERK to induce TRAIL through Foxo3a, possesses superior drug properties: delivery across the blood-brain barrier, superior stability and improved pharmacokinetics. Phase 1/2. ...
Special Price Starting at: $80.00
Keywords:buy CCT128930 | CCT128930 Supplier | purchase CCT128930 | CCT128930 cost | CCT128930 manufacturer | order CCT128930 | CCT128930 distributor | buy 885499-61-6| 885499-61-6 Supplier | purchase 885499-61-6 | 885499-61-6 cost | 885499-61-6 manufacturer | order 885499-61-6 | 885499-61-6 distributor
We Using Safe Payments:
