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CCT128930 is an ATP-competitive AKT inhibitor that is a potent, advanced lead pyrrolopyrimidine compound exhibiting selectivity for AKT over PKA, achieved by targeting a single amino acid difference.
Targets
| Akt2 (Cell-free assay) | p70 S6K (Cell-free assay) | PKA (Cell-free assay) | ||
| 6 nM | 120 nM | 168 nM |
| In vitro (25°C) | DMSO | 68 mg/mL (198.92 mM) | |
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | 6 mg/mL (17.55 mM) | ||
| In vivo | 1% DMSO/30% polyethylene glycol/1% Tween 80 | 11 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 29.26 mL | 146.28 mL | 292.57 mL |
| 0.5 mM | 5.85 mL | 29.26 mL | 58.51 mL |
| 1 mM | 2.93 mL | 14.63 mL | 29.26 mL |
| 5 mM | 0.59 mL | 2.93 mL | 5.85 mL |
*The above data is based on the productmolecular weight 341.8 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Chemical Properties
| Catalog Num | A11031 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 341.8 |
| Formula | C18H20ClN5 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 885499-61-6 |
| Synonyms | CCT-128930 |
| SMILES | C1CN(CCC1(CC2=CC=C(C=C2)Cl)N)C3=NC=NC4=C3C=CN4 |
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