CCT128930

Name: CCT128930
Brand: Adooq Bioscience
SKU: A11031
Rating: 100 (268 reviews)

Catalog No.: A11031

AKT Inhibitor

CCT128930 Chemical Structure

CAS NO. 885499-61-6

CCT128930 is an ATP-competitive AKT inhibitor that is a potent, advanced lead pyrrolopyrimidine compound exhibiting selectivity for AKT over PKA, achieved by targeting a single amino acid difference.

Availability: In stock

Package	Price	Qty
10 mg	$128.00
25 mg	$256.00
50 mg	$450.00
100 mg	$720.00
10mM * 1mL in DMSO	$103.00
Custom Size	Get quote

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Biological Activity

CCT128930 is an ATP-competitive AKT inhibitor that is a potent, advanced lead pyrrolopyrimidine compound exhibiting selectivity for AKT over PKA, achieved by targeting a single amino acid difference.

Targets

Akt2 (Cell-free assay)	p70 S6K (Cell-free assay)	PKA (Cell-free assay)
6 nM	120 nM	168 nM

Solubility *

In vitro (25°C)	DMSO	59 mg/mL (172.59 mM)
	Water	Insoluble
	Ethanol	5 mg/mL (14.63 mM)
In vivo	2% DMSO+30% PEG 300+2% Tween 80+ddH2O	3 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	29.26 mL	146.28 mL	292.57 mL
0.5 mM	5.85 mL	29.26 mL	58.51 mL
1 mM	2.93 mL	14.63 mL	29.26 mL
5 mM	0.59 mL	2.93 mL	5.85 mL

*The above data is based on the productmolecular weight 341.8 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A11031
Actions	Inhibitor
CAS No.	885499-61-6
Formula	C18H20ClN5
M. Wt	341.8
Solubility	DMSO
Purity	>98%
Synonyms	CCT-128930
SMILES	C1CN(CCC1(CC2=CC=C(C=C2)Cl)N)C3=NC=NC4=C3C=CN4
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.