Cathepsin

FA-Phe-Phe is a furylacryloyl (fa)-amino acid derivative that serves as a specific substrate for Cathepsin A. This compound is valuable in elucidating the enzymatic activity and functional mechanisms of Cathepsin A, contributing to research on its role in physiological and pathological processes. FA-Phe-Phe is particularly useful in studies involving enzymatic assays and screening for potential inhibitors or modulators of Cathepsin A.

Gallinamide A is a potent inhibitor of cathepsin L, demonstrating an IC50 value of 17.6 pM. This compound plays a crucial role in research applications focused on investigating the functions of cathepsin L in various biological processes, including protein degradation and immune response regulation. Its inhibitory activity makes Gallinamide A a valuable tool for studying the implications of cathepsin L in pathophysiological conditions.

Cathepsin G(1-5) is an antimicrobial peptide derived from the clostripain-digested cathepsin G mixture. This peptide exhibits significant antimicrobial activity, making it valuable for research on host defense mechanisms and the development of novel therapeutic agents. Cathepsin G(1-5) is utilized in studies exploring its effects on bacterial pathogens and potential applications in infection control.

DCG04 is an activity-based probe targeting cysteine cathepsins, serving as a multivalent ligand for the mannose-6-phosphate receptor. This compound enables the selective labeling of various cysteine cathepsins in cell and tissue lysates, facilitating the study of their roles in physiological and pathological processes. DCG04 is useful for researchers investigating enzyme activity and potential therapeutic interventions involving cysteine cathepsins.

Ac-KQKLR-AMC TFA is a substrate peptide for Cathepsin S, conjugated with the fluorescent indicator AMC (Excitation/Emission = 354 nm/442 nm). This reagent facilitates the measurement of Cathepsin S activity, enabling researchers to study proteolytic processes and assess enzyme function in various biological contexts. Its application is crucial for investigations into the role of Cathepsin S in physiological and pathological conditions.

Cathepsin S, human, is a potent cysteine protease that plays a crucial role in the degradation of damaged or harmful proteins within the endolysosomal pathway. This enzyme is implicated in various pathological processes, including arthritis, cancer, and cardiovascular diseases. Its activity makes it a valuable target for research applications aimed at understanding these diseases and developing therapeutic interventions.

Cathepsin Inhibitor 3 is a selective inhibitor of the serine/threonine protease cathepsin S, functioning as a valuable tool in studying protease-mediated biological processes. This compound serves as a non-radioactive precursor in the synthesis of fluorine-18 radiolabeled compounds, facilitating research in molecular imaging. Additionally, Cathepsin Inhibitor 3 features an alkyne group, enabling its use in copper-catalyzed azide-alkyne cycloaddition (CuAAc), making it a versatile reagent for click chemistry applications in chemical biology.

Cathepsin H, human liver, is a lysosomal cysteine protease that functions as both an aminopeptidase and an endopeptidase. This enzyme is essential for the catabolism of proteins within the lysosomal system. It plays a significant role in regulating tumor cell behavior and is implicated in the pathological processes of various brain diseases, making it valuable for research in cancer biology and neurodegenerative disorders.

Bz-RGFFP-4MβNA is a specific substrate for Cathepsin D, designed for use in either colorimetric or fluorometric assays. It enables the detection and quantification of Cathepsin D activity, making it a valuable tool for studying proteolytic processes and their implications in various biological conditions. This compound facilitates research in areas including cancer, neurodegenerative diseases, and other pathologies where Cathepsin D plays a critical role.

Ac-KQKLR-AMC is a substrate peptide designed for the fluorescent monitoring of Cathepsin S activity. Labeled with AMC, this compound exhibits excitation and emission wavelengths of 354 nm and 442 nm, respectively. It is primarily utilized in biochemical assays to measure the enzymatic activity of Cathepsin S, providing valuable insights into its role in physiological and pathological processes.

Cathepsin D (CTSD) is a lysosomal aspartic protease that plays a critical role in regulating lysosomal protease activity. Disruption of Cathepsin D function is associated with lysosomal dysfunction and the accumulation of proteins implicated in neurodegenerative diseases. Additionally, Cathepsin D is involved in the metastatic progression of breast cancer. This reagent is valuable for research applications related to cancer biology, neurodegeneration, and lysosomal disorders.

Cathepsin-IN-5 is a selective inhibitor of cathepsins L and S, exhibiting IC50 values of 6.2 μM and 81 nM, respectively. This compound effectively inhibits cancer cell proliferation and induces apoptosis, while also reducing the growth of hepatocellular tumors in mouse models. Additionally, Cathepsin-IN-5 modulates the expression of genes associated with cell death and proliferation, making it a valuable reagent for research into hepatocellular carcinoma.