Cathepsin

Cat. No.

A13593

CAS No.

147859-80-1

CA-074 Methyl Ester

Synonyms: CA-074 Me

CA-074 methyl ester is a cell-permeable analog of CA-074 that acts as an irreversible cathepsin B inhibitor. CA-074 methyl ester is reported to inhibit bone resorption in rodent models and shown to inhibit B16 melanoma cell invasion in vitro.

Cat. No.

A13502

CAS No.

907559-59-5

Z-FL-COCHO (LY3000328)

Synonyms: Cathepsin S inhibitor; LY3000328

Z-FL-COCHO (LY3000328) is a novel Cathepsin S inhibitor.  

Cat. No.

A13256

CAS No.

134448-10-5

CA-074

CA-074 is a potent inhibitor of cathepsin B with a Ki of 2 to 5 nM.

Cat. No.

A21069

CAS No.

1310340-58-9

VBY-825

VBY-825 is a novel, reversible cathepsin inhibitor with high potency against cathepsins B, L, S and V.

Cat. No.

A11265

CAS No.

603139-19-1

Odanacatib (MK-0822)

Synonyms: MK0822

Odanacatib is an inhibitor of cathepsin K,an enzyme involved in bone resorption.

Cat. No.

A11466

CAS No.

225120-65-0

Cathepsin Inhibitor 1

Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively.

Cat. No.

A12020

CAS No.

354813-19-7

Balicatib

Synonyms: AAE581; AAE-581,AAE 581

Balicatib, a cathepsin K inhibitor, stimulates periosteal bone formation in monkeys.

Cat. No.

A12487

CAS No.

603139-12-4

L-873724

L-873724 is a potent, orally bioavailable, selective and reversible non-basic cathepsin K inhibitor.

Cat. No.

A13394

CAS No.

1252637-35-6

Petesicatib

Petesicatib is a cathepsin S inhibitor, used in research of immune diseases.

Cat. No.

A14262

CAS No.

26305-03-3

Pepstatin A

Synonyms: Pepstation-A

Pepstatin A is a potent aspartic protease inhibitor, and also inhibits HIV replication.

Cat. No.

A15302

CAS No.

294623-49-7

L 006235

L006235 is a potent, reversible cathepsin K inhibitor (IC50 = 0.25 nM) that displays > 4000-fold selectivity over cathepsins B, L and S.

Cat. No.

A15313

CAS No.

958772-66-2

SID 26681509

SID 26681509 is a reversible and potent human cathepsin L inhibitor. SID 26681509 displays no inhibitory activity of cathepsin G.

Cat. No.

A15685

CAS No.

1373215-15-6

LY3000328

LY3000328 is a Cathepsin S inhibitor with excellent in vitro potency and selectivity against other cysteine proteases.

Cat. No.

A20122

CAS No.

1352817-76-5

MIV-247

MIV-247 is a selective cathepsin S inhibitor with Kis of 2.1, 4.2 and 7.5 nM for human, mouse and cynomolgus monkey cathepsin S, respectively.

Cat. No.

A21558

CAS No.

887781-62-6

MK-0674

MK-0674 is a potent, orally bioavailable and selective cathepsin K inhibitor, with an IC50 of 0.4 nM, shows 1156, 1465, 11857 and 243 fold selectivity over Cat B, Cat F, Cat L and Cat S.

Cat. No.

A22503

CAS No.

1014405-03-8

Oxocarbazate

Synonyms: CID 23631927

Oxocarbazate, also known as CID23631927, is an inhibitor of human cathepsin L.

Cat. No.

A24230

CAS No.

167498-29-5

Z-FY-CHO (Z-Phe-Tyr-CHO)

Synonyms: Z-Phe-Tyr-CHO

Z-FY-CHO (Z-Phe-Tyr-CHO) is a potent and specific inhibitor of cathepsin L (CTSL), a lysosomal cysteine protease involved in protein degradation and various pathological processes. It is commonly used as a tool compound in studies of CTSL-related functions and diseases.

Cat. No.

A25310

CAS No.

96922-64-4

(Rac)-Z-FA-FMK

(Rac)-Z-FA-FMK is a potent inhibitor of cathepsin B, exhibiting a Ki value of 1.5 μM. This compound also inhibits multiple caspases, specifically caspases 2, 3, 6, 7, and 9, with IC50 values ranging from 6.147 to 110.7 μM. Additionally, (Rac)-Z-FA-FMK demonstrates antiviral activity by inhibiting the main protease involved in SARS-CoV-2 replication with an IC50 of 11.39 μM. It further attenuates the increase in IL-1β levels induced by LPS and represses NF-κB transactivation in macrophages, making it useful for research in inflammation and viral pathogenesis.

Cat. No.

A31345

CAS No.

1563260-97-8

TS-24

TS-24 is a selective inhibitor of cathepsin S, demonstrating an IC50 value of 4.3 μM. This compound has been shown to exhibit radiosensitizing effects in wild-type BRCA1 and triple-negative breast cancer (TNBC) xenograft models, primarily by inducing apoptotic pathways. TS-24 is suitable for research applications focused on cancer therapeutic development and understanding cathepsin-mediated biological processes.

Cat. No.

A31772

CAS No.

84518-80-9

NCO-700

NCO-700 is a potent dual inhibitor of cathepsin B and calcium-activated neutral protease (CANP), exhibiting IC50 values of 0.8 μM and 46 μM, respectively. This compound effectively reduces myocardial fibrin degradation by inhibiting protease activity and demonstrates significant anti-tumor effects on hormone-independent cancer cells, including prostate cancer, by inducing apoptosis. NCO-700 serves as a valuable tool for investigating mechanisms underlying myocardial ischemia and exploring novel treatments for refractory hormone-independent tumors.

Cat. No.

A33315

CAS No.

2450279-41-9

Dual Cathepsin L/JAK-IN-1

Dual Cathepsin L/JAK-IN-1 is a dual inhibitor targeting Cathepsin L (CTSL) and Janus kinases (JAK), exhibiting IC50 values of 0.68 μM for CTSL, 337.1 nM for JAK1, 5.251 nM for JAK2, 27.29 nM for JAK3, and 172.6 nM for TYK2. This compound effectively inhibits the activation of key signaling pathways, including MAPK, NF-κB, and JAK/STAT, thereby providing substantial anti-inflammatory effects. Dual Cathepsin L/JAK-IN-1 is useful for investigating mechanisms underlying acute lung injury (ALI) and other inflammatory conditions.

Cat. No.

A36022

CAS No.

3077842-39-5

Cathepsin L-IN-6

Cathepsin L-IN-6 is a selective inhibitor of cathepsin L, exhibiting an IC50 value of 0.021 μM. It functions by directly binding to cathepsin L, effectively suppressing its enzymatic activity. Additionally, Cathepsin L-IN-6 inhibits pro-inflammatory cytokines IL-6 and IL-8, demonstrating significant anti-inflammatory properties. This compound is particularly relevant for research focused on acute lung injury and related inflammatory conditions.

Cat. No.

A37580

CAS No.

587014-85-5

Tasiamide B

Tasiamide B is a potent inhibitor of Cathepsin D and HSP90, derived from the marine cyanobacteria Symploca sp. This linear peptide serves as a valuable scaffold for the development of inhibitors targeting aspartic proteases. Tasiamide B has demonstrated significant efficacy in skin cancer studies by effectively interacting with HSP90, highlighting its potential in cancer research and therapeutic applications.

Cat. No.

A39447

CAS No.

2449093-46-1

LV-320

LV-320 is a potent uncompetitive inhibitor of cathepsin ATG4B, exhibiting an IC50 of 24.5 μM and a Kd of 16 μM. This compound effectively inhibits the enzymatic activity of ATG4B, thereby obstructing autophagic flux in cellular environments. Due to its stability and low toxicity, LV-320 is suitable for in vivo applications, making it a valuable tool for research on autophagy-related pathways.

Cat. No.

A39778

CAS No.

429676-93-7

Cathepsin G Inhibitor I

Cathepsin G Inhibitor I is a potent and selective reversible competitive inhibitor of Cathepsin G, exhibiting an IC50 value of 53 nM and a Ki of 63 nM. This non-peptidic compound is primarily utilized in research investigating immune disorders, providing valuable insights into the role of Cathepsin G in various pathogenic processes. Its specificity makes it a useful tool for understanding the implications of Cathepsin G in immune system regulation.