CGS 8216 is a non-benzodiazepine ligand targeting the GABA receptor, exhibiting high affinity and specificity for rat forebrain membranes. This compound effectively inhibits 3H-flunitrazepam binding to rat synaptosomal membranes, demonstrating potent blocking of 3H-FLU labeling of brain benzodiazepine receptors in vivo, comparable to Diazepam. CGS 8216 is valuable for studying GABAergic signaling and the pharmacological properties of benzodiazepine receptors in neural research applications.
CGS 8216 is a non-benzodiazepine ligand targeting the GABA receptor, exhibiting high affinity and specificity for rat forebrain membranes. This compound effectively inhibits 3H-flunitrazepam binding to rat synaptosomal membranes, demonstrating potent blocking of 3H-FLU labeling of brain benzodiazepine receptors in vivo, comparable to Diazepam. CGS 8216 is valuable for studying GABAergic signaling and the pharmacological properties of benzodiazepine receptors in neural research applications.
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