Fig. 1 · Structure
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CHET3
Cat. No.
A74454
CAS
2489231-47-0
Endogenous Metabolite
CHET3 is an endogenous metabolite that acts as a selective activator of TASK-3-containing K2P channels. It demonstrates significant analgesic activity, effectively modulating the membrane excitability of specific small sensory neurons. Research applications include studying acute and chronic pain models in mice, where CHET3's effects on thermal hypersensitivity and mechanical hyperalgesia can be thoroughly examined. The analgesic effects of CHET3 are sensitive to pharmacological inhibition and genetic knockout of TASK-3, highlighting its precise mechanism of action.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Activator |
| CAS Number | 2489231-47-0 |
| Applications | Endogenous Metabolite |
| Formula | C21H21N5O3S |
| Molecular Weight | 423.49 |
| SMILES | CC(C=C1)=CC=C1SCC(NC(NC(NC2=CC=C(OCCO3)C3=C2)=N)=N4)=CC4=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.