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Catalog No.: A10199

GSK-3 Inhibitor


CHIR-99021 Chemical Structure

CAS NO. 252917-06-9

CHIR99021 is an aminopyrimidine derivative that inhibits GSK3α and GSK3β with IC50 values of 10 and 6.7 nM, respectively.

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  • Adam Pietrobon, .et al. Renal organoid modeling of tuberous sclerosis complex reveals lesion features arise from diverse developmental processes, Cell Rep, 2022, Jul 5;40(1):111048 PMID: 35793620
  • Takayuki Miyoshi, .et al. Successful induction of human chemically induced liver progenitors with small molecules from damaged liver, J Gastroenterol, 2022, Jun;57(6):441-452 PMID: 35294680
  • Tomoki Kamatani, .et al. Evaluation of immunosuppression protocols for MHC-matched allogeneic iPS cell-based transplantation using a mouse skin transplantation model, Inflamm Regen, 2022, Feb 2;42(1):4 PMID: 35105370
  • Dan Zhao, .et al. From crypts to enteroids: establishment and characterization of avian intestinal organoids, Poult Sci, 2022, Mar; 101(3): 101642 PMID: 35016046
  • Otsuka R, .et al. Efficient generation of thymic epithelium from induced pluripotent stem cells that prolongs allograft survival, Sci Rep, 2020, Jan 14;10(1):224 PMID: 31937817
  • Yu Huang, .et al. Development of Bifunctional Three-Dimensional Cysts from Chemically Induced Liver Progenitors, Stem Cells Int, 2019, 2019: 3975689 PMID: 31565060

Biological Activity

CHIR99021 is an aminopyrimidine derivative that inhibits GSK3α and GSK3β with IC50 values of 10 and 6.7 nM, respectively.
GSK-3β GSK-3α
6.7 nM10 nM
In vitro (25°C) DMSO Warmed: 9 mg/mL (19.33 mM)
Water Insoluble
Ethanol Insoluble
In vivo 4% DMSO+30% PEG 300+ddH2O 3.3 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.49 mL 107.46 mL 214.92 mL
0.5 mM 4.3 mL 21.49 mL 42.98 mL
1 mM 2.15 mL 10.75 mL 21.49 mL
5 mM 0.43 mL 2.15 mL 4.3 mL

*The above data is based on the productmolecular weight 465.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10199
Actions Inhibitor
CAS No. 252917-06-9
Formula C22H18Cl2N8
M. Wt 465.3
Purity >98%
Synonyms GSK-3 Inhibitor XVI, CT 99021, CHIR99021

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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