Laduviglusib (CHIR-99021)

Name: Laduviglusib (CHIR-99021)
SKU: A10199
Price: 30 USD
Rating: 5 (13 reviews)

Catalog No.: A10199

GSK-3 Inhibitor

Adooq's Laduviglusib (CHIR-99021) has been cited by 13 publications

CHIR99021 is an aminopyrimidine derivative that inhibits GSK3α and GSK3β with IC50 values of 10 and 6.7 nM, respectively.

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Grouped product items
Size	Price	Stock
2mg	$30.00	In stock
5mg	$50.00	In stock
10mg	$80.00	In stock
25mg	$155.00	In stock
50mg	$260.00	In stock
100mg	$420.00	In stock
200mg	$630.00	In stock
500mg	$980.00	In stock
*10mM 1mL in DMSO**	$55.00	In stock
Bulk Size	Bulk Discount

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Data Sheet

SDS

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Adooq Products cited in reputable paper

Adooq's Laduviglusib (CHIR-99021) has been cited by 13 publications

Peilin Li, .et al. , Ecotoxicol Environ Saf, 2024, Dec:288:117330 PMID: 39571255

Peilin Li, .et al. , Stem Cell Res Ther, 2024, Aug 26;15(1):269 PMID: 39183353

Andreea Manole, .et al. , Cell Rep, 2023, Dec 26;42(12):113466 PMID: 38039131

Claudia Z Han, .et al. , Immunity, 2023, Sep 12;56(9):2152-2171 PMID: 37582369

Eric Lian, .et al. , STAR Protoc, 2023, May 22;4(2):102314 PMID: 37220001

Tomoki Murata, .et al. , Int Immunol, 2023, Apr 13 PMID: 37052267

Shunsuke Murakami, .et al. , Regen Ther, 2022, Nov 25;21:574-583 PMID: 36475025

Adam Pietrobon, .et al. , Cell Rep, 2022, Jul 5;40(1):111048 PMID: 35793620

Takayuki Miyoshi, .et al. , J Gastroenterol, 2022, Jun;57(6):441-452 PMID: 35294680

Tomoki Kamatani, .et al. , Inflamm Regen, 2022, Feb 2;42(1):4 PMID: 35105370

Dan Zhao, .et al. , Poult Sci, 2022, Mar; 101(3): 101642 PMID: 35016046

Otsuka R, .et al. , Sci Rep, 2020, Jan 14;10(1):224 PMID: 31937817

Yu Huang, .et al. , Stem Cells Int, 2019, 2019: 3975689 PMID: 31565060

Biological Activity

Discription

CHIR99021 is an aminopyrimidine derivative that inhibits GSK3α and GSK3β with IC50 values of 10 and 6.7 nM, respectively.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

Product Information

Catalog Num	A10199
Formula	C22H18Cl2N8
Molecular Weight	465.3
CAS Number	252917-06-9
SMILES	CC1=CN=C(N1)C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)Cl)NCCNC4=NC=C(C=C4)C#N
Synonyms	GSK-3 Inhibitor XVI, CT 99021
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility

In vitro (25°C)	DMSO	Warmed: 9 mg/mL (19.33 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	4% DMSO+30% PEG 300+ddH2O	3.3 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.49 mL	107.46 mL	214.92 mL
0.5 mM	4.3 mL	21.49 mL	42.98 mL
1 mM	2.15 mL	10.75 mL	21.49 mL
5 mM	0.43 mL	2.15 mL	4.3 mL

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