Cholesteryl γ-aminobutyrate is a GABA-mimetic prodrug that targets GABA receptors in the central nervous system. It effectively inhibits orthodromically-evoked discharges in pyramidal cells located in the CA1 region of the hippocampus. This compound demonstrates dose-dependent suppression of locomotor activity in rodents and has been shown to inhibit Bicuculline-induced seizures in mice. Cholesteryl γ-aminobutyrate is valuable for research into CNS disorders associated with dysfunctional GABAergic signaling.
Cholesteryl γ-aminobutyrate is a GABA-mimetic prodrug that targets GABA receptors in the central nervous system. It effectively inhibits orthodromically-evoked discharges in pyramidal cells located in the CA1 region of the hippocampus. This compound demonstrates dose-dependent suppression of locomotor activity in rodents and has been shown to inhibit Bicuculline-induced seizures in mice. Cholesteryl γ-aminobutyrate is valuable for research into CNS disorders associated with dysfunctional GABAergic signaling.
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