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Biological Activity
CHZ868 is a potent and selective type II JAK inhibitor which demonstrates activity in JAK inhibitor persistent cells, murine MPN models, and MPN patient samples.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.62 mL | 118.09 mL | 236.17 mL |
| 0.5 mM | 4.72 mL | 23.62 mL | 47.23 mL |
| 1 mM | 2.36 mL | 11.81 mL | 23.62 mL |
| 5 mM | 0.47 mL | 2.36 mL | 4.72 mL |
*The above data is based on the productmolecular weight 423.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A15937 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1895895-38-1 |
| Formula | C22H19F2N5O2 |
| M. Wt | 423.42 |
| Purity | >98% |
| Synonyms | CHZ 868, CHZ-868 |
| SMILES | CC(NC1=NC=CC(OC2=CC=C3N(C)C(NC4=CC=C(F)C=C4F)=NC3=C2C)=C1)=O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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