Fig. 1 · Structure
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Cinanserin hydrochloride
5-HT2 Receptor Antagonist
Cinanserin hydrochloride is a potent and selective antagonist of the 5-HT2 receptor, exhibiting a binding affinity with a Ki of 41 nM. This compound demonstrates a much higher selectivity for the 5-HT2 receptor compared to the 5-HT1 receptor, which has a Ki value of 3500 nM. Additionally, Cinanserin hydrochloride inhibits the 3C-like proteinase of the severe acute respiratory syndrome coronavirus, effectively reducing viral replication in vitro. This dual functionality makes it a valuable tool for research in neuropharmacology and virology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 54-84-2 |
| Applications | 5-HT2 Receptor Antagonist |
| Formula | C20H25ClN2OS |
| Molecular Weight | 376.94 |
| Synonyms | SQ 10643 |
| SMILES | O=C(NC1=CC=CC=C1SCCCN(C)C)/C=C/C2=CC=CC=C2.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.