Fig. 1 · Structure
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CJ-17493
NK1 Receptor Antagonist
CJ-17493 is a neurokinin-1 (NK1) receptor antagonist with a potent Ki of 0.2 nM. This compound also exhibits moderate affinity for the verapamil-binding site of L-type calcium channels (IC50 = 164 nM) and site 2 of sodium channels (IC50 = 48 nM). CJ-17493 is valuable for research applications focused on neurological disorders, providing insights into receptor signaling and potential therapeutic interventions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 225655-10-7 |
| Applications | NK1 Receptor Antagonist |
| Formula | C24H29F3N2O2 |
| Molecular Weight | 434.49 |
| SMILES | FC(F)(F)[C@@](OCC1)(C)C(C1=C2)=CC(CN[C@@H]3[C@H](C4=CC=CC=C4)NCCC3)=C2OC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.