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Biological Activity
CJ-42794 is a selective prostaglandin E receptor subtype 4 (EP4) antagonist, inhibits [3H]-PGE2 binding to the human EP4 receptor with a mean pKi of 8.5, a binding affinity that was at least 200-fold more selective for the human EP4 receptor than other human EP receptor subtypes (EP1, EP2, and EP3).
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 24.16 mL | 120.82 mL | 241.65 mL |
| 0.5 mM | 4.83 mL | 24.16 mL | 48.33 mL |
| 1 mM | 2.42 mL | 12.08 mL | 24.16 mL |
| 5 mM | 0.48 mL | 2.42 mL | 4.83 mL |
*The above data is based on the productmolecular weight 413.83. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A21948 |
|---|---|
| Actions | Antagonist |
| CAS No. | 847728-01-2 |
| Formula | C22H17ClFNO4 |
| M. Wt | 413.83 |
| Purity | >98% |
| Synonyms | CJ-042794, CJ042794, CJ 042794; CJ 42794, CJ42794 |
| SMILES | ClC1=CC=C(OC2=CC=C(F)C=C2)C(C(N[[email protected]](C3=CC=C(C(O)=O)C=C3)C)=O)=C1 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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