CK1-IN-2 hydrochloride

Catalog No.: A36925
CK1 Inhibitor
CK1-IN-2 hydrochloride is a potent inhibitor of casein kinase 1 (CK1), demonstrating IC50 values of 123 nM for CK1a, 19.8 nM for CK1d, 26.8 nM for CK1e, and 74.3 nM for p38a. This compound is valuable for research applications focused on cellular signaling pathways and the modulation of CK1-related processes. Its selective inhibition can help elucidate the role of CK1 in various biological contexts, including cancer and neurodegenerative diseases.
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Adooq Products cited in reputable paper
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Nature Volume 622 Issue 7982 (2023)
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Nature volume 551, pages639-643 (2017)
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Biological Activity
DescriptionCK1-IN-2 hydrochloride is a potent inhibitor of casein kinase 1 (CK1), demonstrating IC50 values of 123 nM for CK1a, 19.8 nM for CK1d, 26.8 nM for CK1e, and 74.3 nM for p38a. This compound is valuable for research applications focused on cellular signaling pathways and the modulation of CK1-related processes. Its selective inhibition can help elucidate the role of CK1 in various biological contexts, including cancer and neurodegenerative diseases.
Product Information
Catalog NumA36925
FormulaC17H13ClFN3O2
Molecular Weight345.76
CAS Number1383377-49-8
SMILESO=C1OCC2=NC=CC(C3=CN(C)N=C3C4=CC=C(F)C=C4)=C12.[H]Cl
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