Clafen (Cyclophosphamide)

Catalog No.: A10224

Clafen (Cyclophosphamide)

Clafen (Cyclophosphamide) Chemical Structure

CAS NO. 50-18-0

Clafen (Cyclophosphamide) is a nitrogen mustard alkylating agent. An alkylating agent adds an alkyl group (CnH2n+1) to DNA. It attaches the alkyl group to the guanine base of DNA, at the number 7 nitrogen atom of the imidazole ring.

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100 mg

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500 mg

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Warning WARNING: Attention California Residents: This product can expose you to chemicals including Clafen (Cyclophosphamide) , which is known to the State of California to cause cancer and birth defects or other reproductive harm. For more information, go to www.P65Warnings.ca.gov
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Takashi Azuma, .et al. Removal of pharmaceuticals in water by introduction of ozonated microbubbles, SEP PURIF TECHNOL, 2019, Apr; 212: 483-489
  • Azuma T, .et al. Distribution of six anticancer drugs and a variety of other pharmaceuticals, and their sorption onto sediments, in an urban Japanese river, Environ Sci Pollut Res Int, 2017, Aug;24(23):19021-19030 PMID: 28660504
  • Azuma T, .et al. Detection of pharmaceuticals and phytochemicals together with their metabolites in hospital effluents in Japan, and their contribution to sewage treatment plant influents, Sci Total Environ, 2016, Apr 1;548-549:189-197 PMID: 26802347

Biological Activity

Clafen (Cyclophosphamide) is a nitrogen mustard alkylating agent. An alkylating agent adds an alkyl group (CnH2n+1) to DNA. It attaches the alkyl group to the guanine base of DNA, at the number 7 nitrogen atom of the imidazole ring.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 38.3 mL 191.5 mL 383 mL
0.5 mM 7.66 mL 38.3 mL 76.6 mL
1 mM 3.83 mL 19.15 mL 38.3 mL
5 mM 0.77 mL 3.83 mL 7.66 mL

*The above data is based on the productmolecular weight 261.1. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10224
CAS No. 50-18-0
Formula C7H15Cl2N2O2P
M. Wt 261.1
Purity >98%
Synonyms Endoxan, Cytoxan, Neosar, Procytox, Revimmune, Cytophosphane
SMILES C1CNP(=O)(OC1)N(CCCl)CCCl
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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