Claturafenib is a potent, orally active pan-mutant BRAF inhibitor. It effectively inhibits phosphorylated ERK (pERK) in cells, demonstrating an IC50 value of 1.6 nM in HT29 cell lines. Claturafenib exhibits significant antitumor activity against non-small cell lung cancer (NSCLC) harboring the BRAFG469A mutation and melanoma with the BRAFK601E mutation, making it a valuable tool for cancer research focused on BRAF mutant pathways.
Claturafenib is a potent, orally active pan-mutant BRAF inhibitor. It effectively inhibits phosphorylated ERK (pERK) in cells, demonstrating an IC50 value of 1.6 nM in HT29 cell lines. Claturafenib exhibits significant antitumor activity against non-small cell lung cancer (NSCLC) harboring the BRAFG469A mutation and melanoma with the BRAFK601E mutation, making it a valuable tool for cancer research focused on BRAF mutant pathways.
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