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- Xie J, .et al. Optimization of a clofarabine-based drug combination regimen for the preclinical evaluation of pediatric acute lymphoblastic leukemia, Pediatr Blood Cancer, 2019, Dec 25:e28133 PMID: 31876116
Biological Activity
Clofarabine is a second generation purine nucleoside analog with antineoplastic activity
Targets
| Ribonucleotide reductase | ||||
| 65 nM |
| In vitro (25°C) | DMSO | 55 mg/mL (181.11 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 2% DMSO+30% PEG 300 +1% Tween 80+ddH2O | 7 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 32.93 mL | 164.64 mL | 329.27 mL |
| 0.5 mM | 6.59 mL | 32.93 mL | 65.85 mL |
| 1 mM | 3.29 mL | 16.46 mL | 32.93 mL |
| 5 mM | 0.66 mL | 3.29 mL | 6.59 mL |
*The above data is based on the productmolecular weight 303.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10228 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 123318-82-1 |
| Formula | C10H11ClFN5O3 |
| M. Wt | 303.7 |
| Purity | >98% |
| Synonyms | Clolar, Evoltra |
| SMILES | C1=NC2=C(N1[[email protected]]3[[email protected]]([[email protected]@H]([[email protected]](O3)CO)O)F)N=C(N=C2N)Cl |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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