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Catalog No.: A10228

DNA/RNA Synthesis inhibitor


Clofarabine Chemical Structure

CAS NO. 123318-82-1

Clofarabine is a second generation purine nucleoside analog with antineoplastic activity

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10 mg
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10mM * 1mL in DMSO
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Xie J, .et al. Optimization of a clofarabine-based drug combination regimen for the preclinical evaluation of pediatric acute lymphoblastic leukemia, Pediatr Blood Cancer, 2019, Dec 25:e28133 PMID: 31876116

Biological Activity

Clofarabine is a second generation purine nucleoside analog with antineoplastic activity
Ribonucleotide reductase
65 nM
In vitro (25°C) DMSO 55 mg/mL (181.11 mM)
Water Insoluble
Ethanol Insoluble
In vivo 2% DMSO+30% PEG 300 +1% Tween 80+ddH2O 7 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 32.93 mL 164.64 mL 329.27 mL
0.5 mM 6.59 mL 32.93 mL 65.85 mL
1 mM 3.29 mL 16.46 mL 32.93 mL
5 mM 0.66 mL 3.29 mL 6.59 mL

*The above data is based on the productmolecular weight 303.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10228
Actions Inhibitor
CAS No. 123318-82-1
Formula C10H11ClFN5O3
M. Wt 303.7
Purity >98%
Synonyms Clolar, Evoltra
SMILES C1=NC2=C(N1[[email protected]]3[[email protected]]([[email protected]@H]([[email protected]](O3)CO)O)F)N=C(N=C2N)Cl

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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