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$0.00 - Milan D Valyear, .et al. Dissociable mesolimbic dopamine circuits control responding triggered by alcohol-predictive discrete cues and contexts, Nat Commun, 2020, Jul 28;11(1):3764 PMID: 32724058
- Yutaro Kobayashi, .et al. Clozapine-dependent inhibition of EGF/neuregulin receptor (ErbB) kinases, Transl Psychiatry, 2019, 9:181 PMID: 31371697
- M.D. Valyear, .et al. Divergent mesolimbic dopamine circuits support alcohol-seeking triggered by discrete cues and contexts, bioRxiv, 2018, 2018
Biological Activity
Clozapine displays a broad range of pharmacological actions; the antipsychotic effects are thought to be mediated principally by 5-HT2A/2C and dopamine receptor blockade.
Targets
| 5-HT2 | ||||
| In vitro | DMSO | 59 mg/mL (180.52 mM) | |
| Water | Insoluble | ||
| Ethanol | 29 mg/mL (88.73 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 30.6 mL | 153 mL | 306 mL |
| 0.5 mM | 6.12 mL | 30.6 mL | 61.2 mL |
| 1 mM | 3.06 mL | 15.3 mL | 30.6 mL |
| 5 mM | 0.61 mL | 3.06 mL | 6.12 mL |
*The above data is based on the productmolecular weight 326.8 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10236 |
|---|---|
| CAS No. | 5786-21-0 |
| Formula | C18H19ClN4 |
| M. Wt | 326.8 |
| Solubility | DMSO |
| Purity | >98% |
| Synonyms | Clozaril, Fazaclo, HF 1854, Iprox, Klozapol, Leponex |
| SMILES | CN1CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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