CM-579 trihydrochloride is a reversible dual inhibitor targeting G9a and DNMT, demonstrating IC50 values of 16 nM and 32 nM, respectively. This compound exhibits significant in vitro cellular activity across various cancer cell types, making it a valuable tool for epigenetic research and cancer therapeutics. Its ability to modulate histone methylation and DNA methylation positions CM-579 trihydrochloride as a key reagent for studies investigating the role of these enzymes in oncogenesis and potential treatment strategies.
CM-579 trihydrochloride is a reversible dual inhibitor targeting G9a and DNMT, demonstrating IC50 values of 16 nM and 32 nM, respectively. This compound exhibits significant in vitro cellular activity across various cancer cell types, making it a valuable tool for epigenetic research and cancer therapeutics. Its ability to modulate histone methylation and DNA methylation positions CM-579 trihydrochloride as a key reagent for studies investigating the role of these enzymes in oncogenesis and potential treatment strategies.
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