CM-579

Catalog No.: A18692

G9a/DNMT inhibitor

CM-579

CM-579 Chemical Structure

CAS NO. 1846570-40-8

CM-579 is a first-in-class reversible, dual inhibitor of G9a and DNMT, with IC50 values of 16 nM, 32 nM for G9a and DNMT, respectively. Has potent in vitro cellular activity in a wide range of cancer cells.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $220.00

Special Price $176.00

10 mg

Regular Price: $360.00

Special Price $288.00

50 mg

Regular Price: $980.00

Special Price $784.00

100 mg

Regular Price: $1,360.00

Special Price $1,088.00

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Biological Activity

CM-579 is a first-in-class reversible, dual inhibitor of G9a and DNMT, with IC50 values of 16 nM, 32 nM for G9a and DNMT, respectively. Has potent in vitro cellular activity in a wide range of cancer cells.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.3 mL 101.49 mL 202.98 mL
0.5 mM 4.06 mL 20.3 mL 40.6 mL
1 mM 2.03 mL 10.15 mL 20.3 mL
5 mM 0.41 mL 2.03 mL 4.06 mL

*The above data is based on the productmolecular weight 492.65. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A18692
Actions Inhibitor
CAS No. 1846570-40-8
Formula C27H35N4O3
M. Wt 492.65
Purity >98%
Synonyms CM579, CM 579
SMILES COC1=C(OCCCN2CCCC2)C=C(N=C(C3=CC=C(C)O3)C=C4NC5CCC[N]C5)C4=C1
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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