CMPD101 hydrochloride is a membrane-permeable inhibitor targeting Rho-associated kinase 2 (ROCK-2), G protein-coupled receptor kinase 2 (GRK2), and GRK3, with IC50 values of 1.4 μM, 18 nM, and 5.4 nM, respectively. This small-molecule compound also inhibits protein kinase C alpha (PKCα) at an IC50 of 8.1 μM. CMPD101 hydrochloride is useful in research focused on cell signaling, smooth muscle contraction, and potential therapeutic applications in cardiovascular and neurological disorders.
CMPD101 hydrochloride is a membrane-permeable inhibitor targeting Rho-associated kinase 2 (ROCK-2), G protein-coupled receptor kinase 2 (GRK2), and GRK3, with IC50 values of 1.4 μM, 18 nM, and 5.4 nM, respectively. This small-molecule compound also inhibits protein kinase C alpha (PKCα) at an IC50 of 8.1 μM. CMPD101 hydrochloride is useful in research focused on cell signaling, smooth muscle contraction, and potential therapeutic applications in cardiovascular and neurological disorders.
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