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Cobimetinib (racemate)

Catalog No.: A15050

MEK inhibitor

Cobimetinib (racemate)

Cobimetinib (racemate) Chemical Structure

CAS NO. 934662-91-6

Cobimetinib is a potent, highly selective inhibitor of MEK1/2.

Availability: Out of stock

Package Price
5 mg

Regular Price: $140.00

Special Price $112.00

10 mg

Regular Price: $210.00

Special Price $168.00

25 mg

Regular Price: $420.00

Special Price $336.00

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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Yuki Shimizu, .et al. Acquired resistance to BRAF inhibitors is mediated by BRAF splicing variants in BRAF V600E mutation-positive colorectal neuroendocrine carcinoma, Cancer Lett, 2022, Sep 1;543 PMID: 35724767
  • Chun-Yu Liu, .et al. Varlitinib Downregulates HER/ERK Signaling and Induces Apoptosis in Triple Negative Breast Cancer Cells, Cancers (Basel), 2019, Jan 17;11(1) PMID: 30658422

Biological Activity

Cobimetinib is a potent, highly selective inhibitor of MEK1/2.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.82 mL 94.11 mL 188.21 mL
0.5 mM 3.76 mL 18.82 mL 37.64 mL
1 mM 1.88 mL 9.41 mL 18.82 mL
5 mM 0.38 mL 1.88 mL 3.76 mL

*The above data is based on the productmolecular weight 531.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A15050
Actions Inhibitor
CAS No. 934662-91-6
Formula C21H21F3IN3O2
M. Wt 531.31
Purity >98%
Synonyms GDC-0973 racemate, XL-518, GDC 0973, XL 518, GDC0973, XL518

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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