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$0.00 - Chun-Yu Liu, .et al. Varlitinib Downregulates HER/ERK Signaling and Induces Apoptosis in Triple Negative Breast Cancer Cells, Cancers (Basel), 2019, Jan 17;11(1) PMID: 30658422
Biological Activity
Cobimetinib is a potent, highly selective inhibitor of MEK1/2.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.82 mL | 94.11 mL | 188.21 mL |
| 0.5 mM | 3.76 mL | 18.82 mL | 37.64 mL |
| 1 mM | 1.88 mL | 9.41 mL | 18.82 mL |
| 5 mM | 0.38 mL | 1.88 mL | 3.76 mL |
*The above data is based on the productmolecular weight 531.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A15050 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 934662-91-6 |
| Formula | C21H21F3IN3O2 |
| M. Wt | 531.31 |
| Purity | >98% |
| Synonyms | GDC-0973 racemate, XL-518, GDC 0973, XL 518, GDC0973, XL518 |
| SMILES | C1CCNC(C1)C2(CN(C2)C(=O)C3=C(C(=C(C=C3)F)F)NC4=C(C=C(C=C4)I)F)O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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