Signaling Pathway
Important Notice: For research use only. We do not sell to patients.
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| Discription | Compound 401 is a cell-permeable pyrimido-isoquinolinone compound that acts as a potent, reversible, and ATP-competitive inhibitor of DNA-PK (IC50 = 280 nM) with ~19-fold selectivity over mTOR (IC50 = 5.3 μM). | ||
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| Catalog Num | A11778 |
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| Formula | C16H15N3O2 |
| Molecular Weight | 281.31 |
| CAS Number | 168425-64-7 |
| SMILES | C1COCCN1C2=CC(=O)N3C=CC4=CC=CC=C4C3=N2 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| In vitro | DMSO | 7 mg/mL (24.88 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 35.55 mL | 177.74 mL | 355.48 mL |
| 0.5 mM | 7.11 mL | 35.55 mL | 71.1 mL |
| 1 mM | 3.55 mL | 17.77 mL | 35.55 mL |
| 5 mM | 0.71 mL | 3.55 mL | 7.11 mL |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
