Compound 401

Catalog No.: A11778

DNA-PK inhibitor

Compound 401 Chemical Structure

CAS NO. 168425-64-7

Compound 401 is a cell-permeable pyrimido-isoquinolinone compound that acts as a potent, reversible, and ATP-competitive inhibitor of DNA-PK (IC50 = 280 nM) with ~19-fold selectivity over mTOR (IC50 = 5.3 μM).

Availability: In stock

Package Price Qty
10 mg
$125.00
25 mg
$300.00
50 mg
$460.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Compound 401 is a cell-permeable pyrimido-isoquinolinone compound that acts as a potent, reversible, and ATP-competitive inhibitor of DNA-PK (IC50 = 280 nM) with ~19-fold selectivity over mTOR (IC50 = 5.3 μM).
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 35.55 mL 177.74 mL 355.48 mL
0.5 mM 7.11 mL 35.55 mL 71.1 mL
1 mM 3.55 mL 17.77 mL 35.55 mL
5 mM 0.71 mL 3.55 mL 7.11 mL

*The above data is based on the productmolecular weight 281.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11778
Actions Inhibitor
M. Wt 281.31
Formula C16H15N3O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 168425-64-7
Synonyms N/A
SMILES C1COCCN1C2=CC(=O)N3C=CC4=CC=CC=C4C3=N2

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