Corydine targets HIV-1 reverse transcriptase and the μ-opioid receptor, acting as an inhibitor with an IC50 of 356.7 μg/mL against the enzyme and an EC50 of 0.51 μM at the receptor. It exhibits antinociceptive effects through the modulation of MOR, effectively reducing acetic acid-induced writhing behavior. Corydine has also demonstrated the ability to inhibit the proliferation of various cancer cells and immune cells, making it a valuable reagent for research into HIV infection, visceral pain, and various cancers including leukemia, melanoma, bladder cancer, and colon adenocarcinoma.
Corydine targets HIV-1 reverse transcriptase and the μ-opioid receptor, acting as an inhibitor with an IC50 of 356.7 μg/mL against the enzyme and an EC50 of 0.51 μM at the receptor. It exhibits antinociceptive effects through the modulation of MOR, effectively reducing acetic acid-induced writhing behavior. Corydine has also demonstrated the ability to inhibit the proliferation of various cancer cells and immune cells, making it a valuable reagent for research into HIV infection, visceral pain, and various cancers including leukemia, melanoma, bladder cancer, and colon adenocarcinoma.
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