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Biological Activity
Costunolide is an Inhibitor of human telomerase activity (IC50 = 65 μM in MCF-7 breast cancer cells). It is described to act as an antioxidant, anti-mycobacterial, anti-inflammatory, and anti-viral, with cytotoxic activity.
Targets
| FPTase | Telomerase (MDA-MB-231) | Telomerase (MCF-7) | ||
| 20 μM | 65 μM | 90 μM |
| In vitro (25°C) | DMSO | 43 mg/mL (185.08 mM) | |
| Water | Insoluble | ||
| Ethanol | 1 mg/mL (4.3 mM) | ||
| In vivo | 2% DMSO+corn oil | 9 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 43.05 mL | 215.24 mL | 430.48 mL |
| 0.5 mM | 8.61 mL | 43.05 mL | 86.1 mL |
| 1 mM | 4.3 mL | 21.52 mL | 43.05 mL |
| 5 mM | 0.86 mL | 4.3 mL | 8.61 mL |
*The above data is based on the productmolecular weight 232.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10240 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 553-21-9 |
| Formula | C15H20O2 |
| M. Wt | 232.3 |
| Purity | >98% |
| SMILES | CC1=CCC/C(=C/[[email protected]@H]2[[email protected]@H](CC1)C(=C)C(=O)O2)/C |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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Contact information
United StatesAdooq Bioscience
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Email: [email protected]
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