CP-288886 is a potent cysLT1 receptor antagonist, demonstrating a Ki value of 0.004 μM. It effectively inhibits calcium mobilization in human U937 cells, with an IC50 of 0.0005 μM. This compound exhibits promising anti-asthmatic activity in preclinical models, such as the guinea pig asthma model, making it a valuable tool for researching respiratory diseases, particularly asthma. Its high oral bioavailability further supports its potential for in vivo studies.
CP-288886 is a potent cysLT1 receptor antagonist, demonstrating a Ki value of 0.004 μM. It effectively inhibits calcium mobilization in human U937 cells, with an IC50 of 0.0005 μM. This compound exhibits promising anti-asthmatic activity in preclinical models, such as the guinea pig asthma model, making it a valuable tool for researching respiratory diseases, particularly asthma. Its high oral bioavailability further supports its potential for in vivo studies.
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