Fig. 1 · Structure
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CP-601932
α3β4 nAChR Agonist
CP-601932 is a high-affinity partial agonist targeting the α3β4 nicotinic acetylcholine receptor (nAChR), with a Ki of 21 nM and an EC50 of approximately 3 μM. It exhibits comparable binding affinity at the α4β2 nAChR, while displaying significantly lower affinity for the α6 and α7 subtypes. CP-601932 is demonstrated to selectively reduce ethanol consumption and operant self-administration behaviors following prolonged exposure, suggesting its potential utility in addiction research. Furthermore, this compound effectively penetrates the central nervous system, enabling comprehensive studies of its effects on neurobiology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Partial Agonist |
| CAS Number | 357425-68-4 |
| Applications | α3β4 nAChR Agonist |
| Formula | C12H12F3N |
| Molecular Weight | 227.23 |
| Synonyms | (1S,5R)-CP-601927 |
| SMILES | FC(F)(C1=CC=C([C@@H]2C[C@H]3CNC2)C3=C1)F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.