CP-601932 is a high-affinity partial agonist targeting the α3β4 nicotinic acetylcholine receptor (nAChR), with a Ki of 21 nM and an EC50 of approximately 3 μM. It exhibits comparable binding affinity at the α4β2 nAChR, while displaying significantly lower affinity for the α6 and α7 subtypes. CP-601932 is demonstrated to selectively reduce ethanol consumption and operant self-administration behaviors following prolonged exposure, suggesting its potential utility in addiction research. Furthermore, this compound effectively penetrates the central nervous system, enabling comprehensive studies of its effects on neurobiology.
CP-601932 is a high-affinity partial agonist targeting the α3β4 nicotinic acetylcholine receptor (nAChR), with a Ki of 21 nM and an EC50 of approximately 3 μM. It exhibits comparable binding affinity at the α4β2 nAChR, while displaying significantly lower affinity for the α6 and α7 subtypes. CP-601932 is demonstrated to selectively reduce ethanol consumption and operant self-administration behaviors following prolonged exposure, suggesting its potential utility in addiction research. Furthermore, this compound effectively penetrates the central nervous system, enabling comprehensive studies of its effects on neurobiology.
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