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- Takuji Sakuratani, .et al. Downregulation of ARID1A in gastric cancer cells: a putative protective molecular mechanism against the Harakiri-mediated apoptosis pathway, Virchows Arch, 2020, Aug 13 PMID: 32789692
- Egawa Y, .et al. Therapeutic potential of CPI-613 for targeting tumorous mitochondrial energy metabolism and inhibiting autophagy in clear cell sarcoma, PLoS One, 2018, Jun 7;13(6):e0198940 PMID: 29879220
Biological Activity
CPI-613 is a racemic mixture of the enantiomers of a synthetic alpha-lipoic lipoic acid analogue with potential chemopreventive and antineoplastic activities.
Targets
| PDH (NCI-H460 cells) | α-ketoglutarate dehydrogenase (NCI-H460 cells) | |||
| In vitro (25°C) | DMSO | 74 mg/mL (190.43 mM) | |
| Water | Insoluble | ||
| Ethanol | 74 mg/mL (190.43 mM) | ||
| In vivo | 2% DMSO+corn oil | 13 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 25.73 mL | 128.67 mL | 257.33 mL |
| 0.5 mM | 5.15 mL | 25.73 mL | 51.47 mL |
| 1 mM | 2.57 mL | 12.87 mL | 25.73 mL |
| 5 mM | 0.51 mL | 2.57 mL | 5.15 mL |
*The above data is based on the productmolecular weight 388.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11786 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 95809-78-2 |
| Formula | C22H28O2S2 |
| M. Wt | 388.6 |
| Purity | >98% |
| Synonyms | CPI613 |
| SMILES | C1=CC=C(C=C1)CSCCC(CCCCC(=O)O)SCC2=CC=CC=C2 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
Datasheet
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Contact information
United StatesAdooq Bioscience
Toll Free: (866) 930-6790
Fax: +1-323-606-8156
Email: [email protected]
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