Fig. 1 · Structure
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CT-996
GLP-1R Agonist
CT-996 is an orally active GLP-1 receptor (GLP-1R) agonist with an EC50 of 0.49 nM, modulating glucose metabolism through its effects on β-arrestin recruitment and receptor internalization. This compound significantly lowers postprandial blood glucose levels in mice engineered to express human GLP-1 receptors and enhances glucose-stimulated insulin secretion (GSIS) in obese monkey models during intravenous glucose challenges. CT-996 serves as a valuable tool for research focused on type 2 diabetes and obesity.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 2810808-95-6 |
| Applications | GLP-1R Agonist |
| Formula | C30H31F2N5O5 |
| Molecular Weight | 579.59 |
| Synonyms | RO7795081; RG6652 |
| SMILES | C[C@@H](C[C@H](CC1)OC2=NC(COC3=C(C=C(C=C3)F)F)=NC=C2)N1CC(N(C4=C5)C[C@@H]6CCO6)=NC4=CC=C5C(O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.