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Biological Activity
CVT-12012 is a potent and orally bioavailable stearoyl-coA desaturase (SCD) inhibitor, with IC50s of 38 nM, 6.1 nM for rat microsomal and human HEPG2, respectively.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.02 mL | 115.1 mL | 230.2 mL |
| 0.5 mM | 4.6 mL | 23.02 mL | 46.04 mL |
| 1 mM | 2.3 mL | 11.51 mL | 23.02 mL |
| 5 mM | 0.46 mL | 2.3 mL | 4.6 mL |
*The above data is based on the productmolecular weight 434.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A21447 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1018675-35-8 |
| Formula | C21H21F3N4O3 |
| M. Wt | 434.41 |
| Purity | >98% |
| Synonyms | CVT12012, CVT 12012 |
| SMILES | O=C(NCCN1C(C(C)=NC2=C1C=C(NCC3=CC=CC(C(F)(F)F)=C3)C=C2)=O)CO |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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